Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

K Labib, JF Diffley

    Research output: Contribution to journalReview article

    118 Citations (Scopus)

    Abstract

    The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.

    Original languageEnglish
    Pages (from-to)64-70
    Number of pages7
    JournalCurrent Opinion in Genetics & Development
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - Feb 2001

    Keywords

    • FISSION YEAST
    • PROTEIN
    • CDC18
    • S-PHASE
    • PHOSPHORYLATION
    • TRANSCRIPTION
    • SUBCELLULAR-LOCALIZATION
    • ENCODES
    • SACCHAROMYCES-CEREVISIAE
    • MITOSIS

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