Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

K Labib; JF Diffley

doi:10.1016/S0959-437X(00)00158-1

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

K Labib, JF Diffley

Research output: Contribution to journal › Review article › peer-review

129 Citations (Scopus)

Abstract

The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.

Original language	English
Pages (from-to)	64-70
Number of pages	7
Journal	Current Opinion in Genetics & Development
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(00)00158-1
Publication status	Published - Feb 2001

Keywords

FISSION YEAST
PROTEIN
CDC18
S-PHASE
PHOSPHORYLATION
TRANSCRIPTION
SUBCELLULAR-LOCALIZATION
ENCODES
SACCHAROMYCES-CEREVISIAE
MITOSIS

Access to Document

10.1016/S0959-437X(00)00158-1

Cite this

@article{ca476c47aa2a4304a4253059fb62853d,

title = "Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?",

abstract = "The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.",

keywords = "FISSION YEAST, PROTEIN, CDC18, S-PHASE, PHOSPHORYLATION, TRANSCRIPTION, SUBCELLULAR-LOCALIZATION, ENCODES, SACCHAROMYCES-CEREVISIAE, MITOSIS",

author = "K Labib and JF Diffley",

year = "2001",

month = feb,

doi = "10.1016/S0959-437X(00)00158-1",

language = "English",

volume = "11",

pages = "64--70",

journal = "Current Opinion in Genetics & Development",

issn = "0959-437X",