Is there an interaction between the cardiovascular protective effects of low-dose aspirin and ibuprofen?

Thomas M. MacDonald (Lead / Corresponding author), Li Wei

    Research output: Contribution to journalShort surveypeer-review

    28 Citations (Scopus)

    Abstract

    Laboratory studies and studies in normal volunteers have suggested a possible adverse interaction between aspirin and ibuprofen. It is thought that ibuprofen prevents aspirin from gaining access to platelet cyclooxygenase. Following the publication of these studies, a number of observational and other studies have been published. We review these studies identified by structured searching of Medline and Pubmed databases. We conclude that on the balance of probabilities that ibuprofen is more likely to interact with aspirin than not. This interaction is more likely in those who take ibuprofen chronically and is more important in those at high cardiovascular risk. Thus, a reasonable strategy might be to advise aspirin takers to avoid chronic ibuprofen.

    Original languageEnglish
    Pages (from-to)275-280
    Number of pages6
    JournalBasic and Clinical Pharmacology and Toxicology
    Volume98
    Issue number3
    DOIs
    Publication statusPublished - Mar 2006

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