Islet cells in human type 1 diabetes: from recent advances to novel therapies - a symposium-based roadmap for future research

TY - JOUR

T1 - Islet cells in human type 1 diabetes

T2 - from recent advances to novel therapies - a symposium-based roadmap for future research

AU - Cantley, James

AU - Eizirik, Decio Laks

AU - Latres, Esther

AU - Dayan, Colin M.

N1 - Funding Information: We would like to thank the JDRF and DiabetesUK for sponsoring this symposium. JC is funded by a Steve Morgan Foundation Type 1 Diabetes Grand Challenge Senior Research Fellowship (22/0006505), the Medical Research Council (MR/W019590/1) and Tenovus Scotland (T20-69). CD holds research funding from JDRF, DiabetesUK and NIHR. Copyright: © 2023 the author(s).

PY - 2023/8/31

Y1 - 2023/8/31

N2 - There is a growing understanding that the early phases of type 1 diabetes (T1D) are characterised by a deleterious dialogue between the pancreatic beta cells and the immune system. This, combined with the urgent need to better translate this growing knowledge into novel therapies, provided the background for the JDRF-DiabetesUK-INNODIA-nPOD symposium entitled 'Islet cells in human T1D: from recent advances to novel therapies', which took place in Stockholm, Sweden, in September 2022. We provide in this article an overview of the main themes addressed in the symposium, pointing to both promising conclusions and key unmet needs that remain to be addressed in order to achieve better approaches to prevent or reverse T1D.

AB - There is a growing understanding that the early phases of type 1 diabetes (T1D) are characterised by a deleterious dialogue between the pancreatic beta cells and the immune system. This, combined with the urgent need to better translate this growing knowledge into novel therapies, provided the background for the JDRF-DiabetesUK-INNODIA-nPOD symposium entitled 'Islet cells in human T1D: from recent advances to novel therapies', which took place in Stockholm, Sweden, in September 2022. We provide in this article an overview of the main themes addressed in the symposium, pointing to both promising conclusions and key unmet needs that remain to be addressed in order to achieve better approaches to prevent or reverse T1D.

KW - islet

KW - pancreas

KW - insulin secretion

KW - autoimmune

KW - diabetes

UR - https://www.scopus.com/pages/publications/85169293004

U2 - 10.1530/JOE-23-0082

DO - 10.1530/JOE-23-0082

M3 - Review article

C2 - 37493471

SN - 0022-0795

VL - 259

JO - Journal of Endocrinology

JF - Journal of Endocrinology

IS - 1

M1 - e230082

ER -