Abstract
The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-kappa B signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-kappa B signaling pathway. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Original language | English |
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Pages (from-to) | 5711-5715 |
Number of pages | 5 |
Journal | European Journal of Organic Chemistry |
Issue number | 33 |
DOIs | |
Publication status | Published - Nov 2009 |
Keywords
- Natural products
- Total synthesis
- Terpenoids
- Cleavage reaction
- Inflammation
- NF-KAPPA-B
- SESQUITERPENE LACTONES
- NATURAL-PRODUCTS
- DRUG DISCOVERY
- CONSTITUENTS
- INHIBITION