Isolation of labile Fcgamma-receptors from human peripheral blood lymphocytes and production of an antiserum

G. P. Sandilands, Moira G. Peel, Karin S. Froebel, Jill J. F. Belch, R. N. M. MacSween

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    Abstract

    In this study, we have isolated membranelabile Fcgamma-receptors (i.e. FcgammaR I) from normal human peripheral blood lymphocytes and have produced a rabbit antiserum to this protein. Using this antiserum, we have shown that membrane-labile and membrane-stable (i.e. FcgammaR II) Fcgamma-receptors are antigenically distinct and that these two forms of the receptors probably coexist on the same lymphocyte subpopulation. Moreover, it was apparent that lymphocyte FcgammaR Is are distinct from FcgammaRs expressed on other cell types (e.g. monocytes, polymorphs and spermatozoa). Preliminary evidence does suggest, however, that human platelets express an FcgammaR which is antigenically similar to human lymphocyte FcgammaR I.
    Original languageEnglish
    Pages (from-to)7-13
    Number of pages7
    JournalImmunology
    Volume55
    Issue number1
    Publication statusPublished - 1985

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