Projects per year
Abstract
Oxidative stress and inflammation in the brain are two key hallmarks of neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, Huntington’s and multiple sclerosis. The axis NRF2-BACH1 has anti-inflammatory and anti-oxidant properties that could be exploited pharmacologically to obtain neuroprotective effects. Activation of NRF2 or inhibition of BACH1 are, individually, promising therapeutic approaches for NDs. Compounds with dual activity as NRF2 activators and BACH1 inhibitors, could therefore potentially provide a more robust antioxidant and anti-inflammatory effects, with an overall better neuroprotective outcome. The phytocannabinoid cannabidiol (CBD) inhibits BACH1 but lacks significant NRF2 activating properties. Based on this scaffold, we have developed a novel CBD derivative that is highly effective at both inhibiting BACH1 and activating NRF2. This new CBD derivative provides neuroprotection in cell models of relevance to Huntington’s disease, setting the basis for further developments in vivo.
Original language | English |
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Article number | 101689 |
Number of pages | 10 |
Journal | Redox Biology |
Volume | 37 |
Early online date | 22 Aug 2020 |
DOIs | |
Publication status | Published - Oct 2020 |
Keywords
- Cannabidiol derivative
- NRF2
- BACH1
- HMOX1
- Neurodegenerative diseases
- Cannabidiol derivative/ NRF2/ BACH1/ HMOX1/ neurodegenerative diseases
ASJC Scopus subject areas
- Clinical Biochemistry
- Organic Chemistry
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Dive into the research topics of 'Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity'. Together they form a unique fingerprint.Projects
- 3 Finished
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Targeting Tumour Cells with Hyperactive NRF2
de la Vega, L. (Investigator)
1/11/18 → 31/10/21
Project: Research
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HIPK2 as a Novel Determinant of Tumour Progression and Therapeutic Resistance
de la Vega, L. (Investigator)
1/02/17 → 1/02/24
Project: Research
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The Role of the Keap1/Nrf2 Pathway in Tumour Metabolic Adaptation (Joint with University of Cambridge and University College London)
Dinkova-Kostova, A. (Investigator)
1/06/15 → 30/04/21
Project: Research