Isosteres of nucleoside triphosphates

Richard Weaver; Ian H.  Gilbert; Naheed  Mahmood; Jan Balzarini

doi:10.1016/0960-894X(96)00444-1

Isosteres of nucleoside triphosphates

Richard Weaver, Ian H. Gilbert, Naheed Mahmood, Jan Balzarini

Research output: Contribution to journal › Article › peer-review

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Abstract

This paper describes the design and synthesis of lipophilic isosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The isosteric replacement of the triphosphate group is a modification of the citrate group. Copyright (C) 1996 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2405-2410
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	6
Issue number	20
DOIs	https://doi.org/10.1016/0960-894X(96)00444-1
Publication status	Published - 22 Oct 1996

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10.1016/0960-894X(96)00444-1

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title = "Isosteres of nucleoside triphosphates",

abstract = "This paper describes the design and synthesis of lipophilic isosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The isosteric replacement of the triphosphate group is a modification of the citrate group. Copyright (C) 1996 Elsevier Science Ltd.",

author = "Richard Weaver and Gilbert, \{Ian H.\} and Naheed Mahmood and Jan Balzarini",

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AU - Balzarini, Jan

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AB - This paper describes the design and synthesis of lipophilic isosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The isosteric replacement of the triphosphate group is a modification of the citrate group. Copyright (C) 1996 Elsevier Science Ltd.

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DO - 10.1016/0960-894X(96)00444-1

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JO - Bioorganic & Medicinal Chemistry Letters

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Isosteres of nucleoside triphosphates

Abstract

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