Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Linzy Houchen-Wolloff; Krisnah Poinasamy; Kate Holmes; Maryrose Tarpey; Claire Hastie; Kelly Raihani; Natalie Rogers; Nikki Smith; Dawn Adams; Paul Burgess; Jean Clark; Clare Cranage; Mahadev Desai; Nicola Geary; Rhyan Gill; Jitendra Mangwani; Lily Staunton; Colin Berry; Charlotte E. Bolton; Trudie Chalder; James Chalmers; Anthony De Soyza; Omer Elneima; John Geddes; Simon Heller; Ling-Pei Ho; Joseph Jacob; Hamish McAuley; Aarti Parmar; Jennifer K. Quint; Betty Raman; Matthew Rowland; Amisha Singapuri; Sally J. Singh; David Thomas; Mark R. Toshner; Louise V. Wain; Alex Robert Horsley; Michael Marks; Christopher E. Brightling; Rachael A. Evans

doi:10.1136/thoraxjnl-2021-218582

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Linzy Houchen-Wolloff, Krisnah Poinasamy, Kate Holmes, Maryrose Tarpey, Claire Hastie, Kelly Raihani, Natalie Rogers, Nikki Smith, Dawn Adams, Paul Burgess, Jean Clark, Clare Cranage, Mahadev Desai, Nicola Geary, Rhyan Gill, Jitendra Mangwani, Lily Staunton, Colin Berry, Charlotte E. Bolton, Trudie ChalderJames Chalmers, Anthony De Soyza, Omer Elneima, John Geddes, Simon Heller, Ling-Pei Ho, Joseph Jacob, Hamish McAuley, Aarti Parmar, Jennifer K. Quint, Betty Raman, Matthew Rowland, Amisha Singapuri, Sally J. Singh, David Thomas, Mark R. Toshner, Louise V. Wain, Alex Robert Horsley, Michael Marks, Christopher E. Brightling, Rachael A. Evans (Lead / Corresponding author)

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Abstract

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.

Original language	English
Pages (from-to)	717-720
Number of pages	4
Journal	Thorax
Volume	77
Issue number	7
Early online date	30 Mar 2022
DOIs	https://doi.org/10.1136/thoraxjnl-2021-218582
Publication status	Published - Jul 2022

Keywords

COVID-19

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2021-218582Licence: CC BY

Final Published VersionFinal published version, 1.22 MBLicence: CC BY

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Houchen-Wolloff, L., Poinasamy, K., Holmes, K., Tarpey, M., Hastie, C., Raihani, K., Rogers, N., Smith, N., Adams, D., Burgess, P., Clark, J., Cranage, C., Desai, M., Geary, N., Gill, R., Mangwani, J., Staunton, L., Berry, C., Bolton, C. E., ... Evans, R. A. (2022). Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19. Thorax, 77(7), 717-720. https://doi.org/10.1136/thoraxjnl-2021-218582

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title = "Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19",

abstract = "Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.",

keywords = "COVID-19",

author = "Linzy Houchen-Wolloff and Krisnah Poinasamy and Kate Holmes and Maryrose Tarpey and Claire Hastie and Kelly Raihani and Natalie Rogers and Nikki Smith and Dawn Adams and Paul Burgess and Jean Clark and Clare Cranage and Mahadev Desai and Nicola Geary and Rhyan Gill and Jitendra Mangwani and Lily Staunton and Colin Berry and Bolton, {Charlotte E.} and Trudie Chalder and James Chalmers and {De Soyza}, Anthony and Omer Elneima and John Geddes and Simon Heller and Ling-Pei Ho and Joseph Jacob and Hamish McAuley and Aarti Parmar and Quint, {Jennifer K.} and Betty Raman and Matthew Rowland and Amisha Singapuri and Singh, {Sally J.} and David Thomas and Toshner, {Mark R.} and Wain, {Louise V.} and Horsley, {Alex Robert} and Michael Marks and Brightling, {Christopher E.} and Evans, {Rachael A.}",

note = "Funding Information: PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 (grant references: MR/V027859/1 and COV0319). Core funding was provided by NIHR Leicester Biomedical Research Centre to support the PHOSP-COVID coordination team, and NIHR Biomedical Research Centres (BRCs), Clinical Research Facilities (CRF) and NIHR Health Protection Research Unit (HPRU) and Translational Research Collaborations (TRCs) network across the country. This research was funded in whole or in part by the Wellcome Trust [209553/Z/17/Z] for author JJ. RAE held a NIHR Clinical Scientist Fellowship CS-2016-16-020 during the conduct of the study {\textcopyright} Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.",

year = "2022",

month = jul,

doi = "10.1136/thoraxjnl-2021-218582",

language = "English",

volume = "77",

pages = "717--720",

journal = "Thorax",

issn = "0040-6376",

publisher = "BMJ Publishing Group",

number = "7",

}

Houchen-Wolloff, L, Poinasamy, K, Holmes, K, Tarpey, M, Hastie, C, Raihani, K, Rogers, N, Smith, N, Adams, D, Burgess, P, Clark, J, Cranage, C, Desai, M, Geary, N, Gill, R, Mangwani, J, Staunton, L, Berry, C, Bolton, CE, Chalder, T, Chalmers, J, De Soyza, A, Elneima, O, Geddes, J, Heller, S, Ho, L-P, Jacob, J, McAuley, H, Parmar, A, Quint, JK, Raman, B, Rowland, M, Singapuri, A, Singh, SJ, Thomas, D, Toshner, MR, Wain, LV, Horsley, AR, Marks, M, Brightling, CE & Evans, RA 2022, 'Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19', Thorax, vol. 77, no. 7, pp. 717-720. https://doi.org/10.1136/thoraxjnl-2021-218582

TY - JOUR

T1 - Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

AU - Houchen-Wolloff, Linzy

AU - Poinasamy, Krisnah

AU - Holmes, Kate

AU - Tarpey, Maryrose

AU - Hastie, Claire

AU - Raihani, Kelly

AU - Rogers, Natalie

AU - Smith, Nikki

AU - Adams, Dawn

AU - Burgess, Paul

AU - Clark, Jean

AU - Cranage, Clare

AU - Desai, Mahadev

AU - Geary, Nicola

AU - Gill, Rhyan

AU - Mangwani, Jitendra

AU - Staunton, Lily

AU - Berry, Colin

AU - Bolton, Charlotte E.

AU - Chalder, Trudie

AU - Chalmers, James

AU - De Soyza, Anthony

AU - Elneima, Omer

AU - Geddes, John

AU - Heller, Simon

AU - Ho, Ling-Pei

AU - Jacob, Joseph

AU - McAuley, Hamish

AU - Parmar, Aarti

AU - Quint, Jennifer K.

AU - Raman, Betty

AU - Rowland, Matthew

AU - Singapuri, Amisha

AU - Singh, Sally J.

AU - Thomas, David

AU - Toshner, Mark R.

AU - Wain, Louise V.

AU - Horsley, Alex Robert

AU - Marks, Michael

AU - Brightling, Christopher E.

AU - Evans, Rachael A.

N1 - Funding Information: PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 (grant references: MR/V027859/1 and COV0319). Core funding was provided by NIHR Leicester Biomedical Research Centre to support the PHOSP-COVID coordination team, and NIHR Biomedical Research Centres (BRCs), Clinical Research Facilities (CRF) and NIHR Health Protection Research Unit (HPRU) and Translational Research Collaborations (TRCs) network across the country. This research was funded in whole or in part by the Wellcome Trust [209553/Z/17/Z] for author JJ. RAE held a NIHR Clinical Scientist Fellowship CS-2016-16-020 during the conduct of the study © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

PY - 2022/7

Y1 - 2022/7

N2 - Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.

AB - Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.

KW - COVID-19

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U2 - 10.1136/thoraxjnl-2021-218582

DO - 10.1136/thoraxjnl-2021-218582

M3 - Article

C2 - 35354642

SN - 0040-6376

VL - 77

SP - 717

EP - 720

JO - Thorax

JF - Thorax

IS - 7

ER -

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Abstract

Keywords

ASJC Scopus subject areas

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PHOS-COVID (Joint with University of Leicester)

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Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

PHOS-COVID (Joint with University of Leicester)

Cite this