Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein

Keyphrases

• Electrophile 100%
• Kelch-like ECH-associated Protein 1 (Keap1) 100%
• Zinc Metalloprotease 100%
• Zinc 60%
• Inducer 40%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 20%
• Zn2+ 20%
• Cysteine Thiols 20%
• Reactive Cysteines 20%
• Direct Measurement 10%
• Overexpression 10%
• Chemical Modification 10%
• Order of Magnitude 10%
• Actin 10%
• Cysteine 10%
• Cellular Response 10%
• Metal Coordination 10%
• Recombinant 10%
• Nuclear Translocation 10%
• Zinc Binding 10%
• Association Constant 10%
• Antioxidant Response Element 10%
• Thiol Groups 10%
• Electrophilic Stress 10%
• 4,4′-Dipyridyl 10%
• Dipyridyl Disulfide 10%
• Cysteine Residues 10%
• Protein Thiols 10%
• Co2+ 10%
• Hydrophobicity 10%
• Metal Binding 10%
• Optical Spectra 10%
• Metalloproteins 10%
• Nuclear Activation 10%
• Chelator 10%
• Thiol Proteins 10%
• Tryptophan Fluorescence 10%
• Inductively Coupled Plasma Atomic Emission Spectrometry 10%
• Zinc Atom 10%
• Zinc Content 10%
• Thiol Reactivity 10%
• Metal Composition 10%

Biochemistry, Genetics and Molecular Biology

• Zinc 100%
• Metalloprotein 100%
• Thiol 100%
• Cysteine 80%
• Transcription Factor Nrf2 40%
• Actin 20%
• Disulfide 20%
• Conformation 20%
• Antioxidant Responsive Element 20%
• Electrophilic Stress 20%
• Bipyridine 20%
• Murine 20%
• Metal Binding 20%
• Hydrophobicity 20%
• Spectrum 20%
• Alanine 20%
• Tryptophan 20%
• Inductively Coupled Plasma Mass Spectrometry 20%