Ketamine prevents ECS-induced synaptic enhancement in rat hippocampus

Caroline A. Stewart; I. C. Reid

doi:10.1016/0304-3940(94)90277-1

Ketamine prevents ECS-induced synaptic enhancement in rat hippocampus

Caroline A. Stewart, I. C. Reid

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46 Citations (Scopus)

Abstract

Electrical induction of seizure activity profoundly impairs hippocampal long-term potentiation (LTP) in rats. A similar effect may account for the memory dysfunction observed after electroconvulsive stimulation in humans and other species. The co-administration of ketamine with the induction of electroconvulsive seizures (ECS) was evaluated as a possible method for-reducing the impact of ECS on hippocampal synaptic plasticity in rats. Electrophysiological studies in vivo showed that both the enhancement of the EPSP slope and the subsequent reduction of experimentally induced LTP in the dentate gyrus by repeated, spaced ECS were significantly attenuated by ketamine anaesthesia. The findings suggest that ketamine may protect against ECS-induced memory impairment and thus prove useful in reducing the transient cognitive impairment following electroconvulsive therapy (ECT).

Original language	English
Pages (from-to)	11-14
Number of pages	4
Journal	Neuroscience Letters
Volume	178
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90277-1
Publication status	Published - 29 Aug 1994

Keywords

Long-term potentiation
Electroconvulsive stimulation
Dentate gyrus
NMDA receptor
Depression
Memory

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10.1016/0304-3940(94)90277-1

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abstract = "Electrical induction of seizure activity profoundly impairs hippocampal long-term potentiation (LTP) in rats. A similar effect may account for the memory dysfunction observed after electroconvulsive stimulation in humans and other species. The co-administration of ketamine with the induction of electroconvulsive seizures (ECS) was evaluated as a possible method for-reducing the impact of ECS on hippocampal synaptic plasticity in rats. Electrophysiological studies in vivo showed that both the enhancement of the EPSP slope and the subsequent reduction of experimentally induced LTP in the dentate gyrus by repeated, spaced ECS were significantly attenuated by ketamine anaesthesia. The findings suggest that ketamine may protect against ECS-induced memory impairment and thus prove useful in reducing the transient cognitive impairment following electroconvulsive therapy (ECT).",

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AU - Reid, I. C.

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Ketamine prevents ECS-induced synaptic enhancement in rat hippocampus

Abstract

Keywords

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