Key roles for AMP-activated protein kinase in the function of the carotid body?

Christopher N. Wyatt, Selina A. Pearson, Prem Kumar, Chris Peers, D. Grahame Hardie, A. Mark Evans

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

    6 Citations (Scopus)

    Abstract

    The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
    Original languageEnglish
    Title of host publicationIntegration in respiratory control
    Subtitle of host publicationfrom genes to systems
    EditorsMarc J. Poulin, Richard J. A. Wilson
    PublisherSpringer
    Pages63-68
    Number of pages6
    ISBN (Electronic)9780387736938
    ISBN (Print)9780387736921
    DOIs
    Publication statusPublished - 1 Jan 2008

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Number2
    Volume605

    Fingerprint

    Carotid Body
    AMP-Activated Protein Kinases
    Adenosine
    Protein Kinases
    Somatotypes
    Mustard Plant
    Oxidative Phosphorylation
    Oxygen
    Enzymes
    Hypoxia

    Keywords

    • AMP activated protein kinases
    • Multienzyme complex
    • Protein serine threonine kinase
    • Carotid body chemoreceptor
    • Controlled study
    • Hypoxia

    Cite this

    Wyatt, C. N., Pearson, S. A., Kumar, P., Peers, C., Hardie, D. G., & Evans, A. M. (2008). Key roles for AMP-activated protein kinase in the function of the carotid body? In M. J. Poulin, & R. J. A. Wilson (Eds.), Integration in respiratory control: from genes to systems (pp. 63-68). (Advances in Experimental Medicine and Biology; Vol. 605, No. 2). Springer . https://doi.org/10.1007/978-0-387-73693-8_11
    Wyatt, Christopher N. ; Pearson, Selina A. ; Kumar, Prem ; Peers, Chris ; Hardie, D. Grahame ; Evans, A. Mark. / Key roles for AMP-activated protein kinase in the function of the carotid body?. Integration in respiratory control: from genes to systems. editor / Marc J. Poulin ; Richard J. A. Wilson. Springer , 2008. pp. 63-68 (Advances in Experimental Medicine and Biology; 2).
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    Wyatt, CN, Pearson, SA, Kumar, P, Peers, C, Hardie, DG & Evans, AM 2008, Key roles for AMP-activated protein kinase in the function of the carotid body? in MJ Poulin & RJA Wilson (eds), Integration in respiratory control: from genes to systems. Advances in Experimental Medicine and Biology, no. 2, vol. 605, Springer , pp. 63-68. https://doi.org/10.1007/978-0-387-73693-8_11

    Key roles for AMP-activated protein kinase in the function of the carotid body? / Wyatt, Christopher N.; Pearson, Selina A.; Kumar, Prem; Peers, Chris; Hardie, D. Grahame; Evans, A. Mark.

    Integration in respiratory control: from genes to systems. ed. / Marc J. Poulin; Richard J. A. Wilson. Springer , 2008. p. 63-68 (Advances in Experimental Medicine and Biology; Vol. 605, No. 2).

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

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    AU - Wyatt, Christopher N.

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    AU - Kumar, Prem

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    AU - Evans, A. Mark

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    KW - Multienzyme complex

    KW - Protein serine threonine kinase

    KW - Carotid body chemoreceptor

    KW - Controlled study

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    Wyatt CN, Pearson SA, Kumar P, Peers C, Hardie DG, Evans AM. Key roles for AMP-activated protein kinase in the function of the carotid body? In Poulin MJ, Wilson RJA, editors, Integration in respiratory control: from genes to systems. Springer . 2008. p. 63-68. (Advances in Experimental Medicine and Biology; 2). https://doi.org/10.1007/978-0-387-73693-8_11