TY - CHAP
T1 - Key roles for AMP-activated protein kinase in the function of the carotid body?
AU - Wyatt, Christopher N.
AU - Pearson, Selina A.
AU - Kumar, Prem
AU - Peers, Chris
AU - Hardie, D. Grahame
AU - Evans, A. Mark
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
AB - The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
KW - AMP activated protein kinases
KW - Multienzyme complex
KW - Protein serine threonine kinase
KW - Carotid body chemoreceptor
KW - Controlled study
KW - Hypoxia
UR - http://www.scopus.com/inward/record.url?scp=38449112248&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-73693-8_11
DO - 10.1007/978-0-387-73693-8_11
M3 - Other chapter contribution
AN - SCOPUS:38449112248
SN - 9780387736921
T3 - Advances in Experimental Medicine and Biology
SP - 63
EP - 68
BT - Integration in respiratory control
A2 - Poulin, Marc J.
A2 - Wilson, Richard J. A.
PB - Springer
ER -