Kikuchi's disease displaying a t(2:16) chromosomal translocation

Katherine E. Robertson, Peter D. Forsyth, Paul J. Batstone, David A. Levison, John R. Goodlad

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    Abstract

    Kikuchi's disease is a rare self-limiting lymphoproliferative condition of unknown aetiology, characterised by acute or subacute necrotising lymphadenitis. It is a benign condition that can mimic malignant lymphoma. In this report, a case of Kikuchi's disease associated with a chromosomal abnormality is described. This is the first report in the literature of such a case and it highlights an important learning point; benign lymphoproliferative conditions can be associated with chromosomal abnormalities that are more typically associated with malignant lymphoproliferative conditions such as malignant lymphoma. The report illustrates the necessity for interpreting cytogenetic data in the relevant clinical and histopathological context in a multidisciplinary setting to avoid misdiagnosis and inappropriate treatment.
    Original languageEnglish
    Pages (from-to)433-435
    Number of pages3
    JournalJournal of Clinical Pathology
    Volume60
    Issue number4
    DOIs
    Publication statusPublished - Apr 2007

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    Keywords

    • Adult
    • Chromosomes, Human, Pair 16
    • Chromosomes, Human, Pair 2
    • Female
    • Histiocytic Necrotizing Lymphadenitis
    • Humans
    • Karyotyping
    • Lymph Nodes
    • Translocation, Genetic

    Cite this

    Robertson, K. E., Forsyth, P. D., Batstone, P. J., Levison, D. A., & Goodlad, J. R. (2007). Kikuchi's disease displaying a t(2:16) chromosomal translocation. Journal of Clinical Pathology, 60(4), 433-435. https://doi.org/10.1136/jcp.2006.038646