Kinase drug discovery: What's next in the field?

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• Finished

  Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

  Cohen, P. (Investigator)

  1/04/13 → 31/03/18

  Project: Research

  • Ubiquitin 100%
  • Phosphorylation 82%
  • Signaling Network 78%
  • Protein Kinase 74%
  • Toll-like 72%

• Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

  Cohen, P. (Investigator)

  Medical Research Council

  1/04/13 → 31/03/18

  Project: Research

  • Ubiquitin 100%
  • Phosphorylation 68%
  • Ubiquitin Chains 64%
  • Toll-like 58%
  • Kinase 52%

• A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

  Alessi, D. (Investigator)

  Medical Research Council

  1/09/10 → 31/08/15

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 53%
  • Leucine-Rich Repeat 46%
  • Phosphorylation 36%