Kindlin-3 in the immune system

Susanna C Fagerholm; Hwee San Lek; Vicky L Morrison

Kindlin-3 in the immune system

Susanna C Fagerholm (Lead / Corresponding author), Hwee San Lek, Vicky L Morrison

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Abstract

Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

Original language	English
Pages (from-to)	37-42
Number of pages	6
Journal	American Journal of Clinical and Experimental Immunology
Volume	3
Issue number	1
Publication status	Published - 2014

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AB - Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

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Kindlin-3 in the immune system

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