Kindlin-3 in the immune system

Susanna C Fagerholm (Lead / Corresponding author), Hwee San Lek, Vicky L Morrison

    Research output: Contribution to journalArticle

    25 Downloads (Pure)

    Abstract

    Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.
    Original languageEnglish
    Pages (from-to)37-42
    Number of pages6
    JournalAmerican Journal of Clinical and Experimental Immunology
    Volume3
    Issue number1
    Publication statusPublished - 2014

    Fingerprint

    Integrins
    CD18 Antigens
    Immune System
    CD29 Antigens
    Integrin beta Chains
    Hematopoietic System
    Inborn Genetic Diseases
    Focal Adhesions
    Platelet Activation
    Proteins
    Leukocytes
    Hemorrhage
    Mutation
    Infection
    Type III Leukocyte Adhesion Deficiency

    Cite this

    Fagerholm, S. C., Lek, H. S., & Morrison, V. L. (2014). Kindlin-3 in the immune system. American Journal of Clinical and Experimental Immunology, 3(1), 37-42.
    Fagerholm, Susanna C ; Lek, Hwee San ; Morrison, Vicky L. / Kindlin-3 in the immune system. In: American Journal of Clinical and Experimental Immunology. 2014 ; Vol. 3, No. 1. pp. 37-42.
    @article{5abe5822fe9b42cebe95a6405e9f26a7,
    title = "Kindlin-3 in the immune system",
    abstract = "Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.",
    author = "Fagerholm, {Susanna C} and Lek, {Hwee San} and Morrison, {Vicky L}",
    year = "2014",
    language = "English",
    volume = "3",
    pages = "37--42",
    journal = "American Journal of Clinical and Experimental Immunology",
    issn = "2164-7712",
    publisher = "e-Century Publishing Corporation",
    number = "1",

    }

    Fagerholm, SC, Lek, HS & Morrison, VL 2014, 'Kindlin-3 in the immune system', American Journal of Clinical and Experimental Immunology, vol. 3, no. 1, pp. 37-42.

    Kindlin-3 in the immune system. / Fagerholm, Susanna C (Lead / Corresponding author); Lek, Hwee San; Morrison, Vicky L.

    In: American Journal of Clinical and Experimental Immunology, Vol. 3, No. 1, 2014, p. 37-42.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Kindlin-3 in the immune system

    AU - Fagerholm, Susanna C

    AU - Lek, Hwee San

    AU - Morrison, Vicky L

    PY - 2014

    Y1 - 2014

    N2 - Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

    AB - Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

    M3 - Article

    VL - 3

    SP - 37

    EP - 42

    JO - American Journal of Clinical and Experimental Immunology

    JF - American Journal of Clinical and Experimental Immunology

    SN - 2164-7712

    IS - 1

    ER -