Kinetochore-microtubule interactions: steps towards bi-orientation

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    Abstract

    Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis, which is necessary for maintenance of their genetic integrity. This process mainly relies on the forces generated by kinetochore-microtubule (KT-MT) attachment. During prometaphase, the KT initially interacts with a single MT extending from a spindle pole and then moves towards a spindle pole. Subsequently, MTs from the other spindle pole also interact with the KT. Eventually, one sister KT becomes attached to MTs from one pole while the other sister to those from the other pole (sister KT bi-orientation). If sister KTs interact with MTs with aberrant orientation, this must be corrected to attain proper bi-orientation (error correction) before the anaphase is initiated. Here, I discuss how KTs initially interact with MTs and how this interaction develops into bi-orientation; both processes are fundamentally crucial for proper chromosome segregation in the subsequent anaphase. The EMBO Journal (2010) 29, 4070-4082. doi: 10.1038/emboj.2010.294; Published online 23 November 2010

    Original languageEnglish
    Pages (from-to)4070-4082
    Number of pages13
    JournalEMBO Journal
    Volume29
    Issue number24
    DOIs
    Publication statusPublished - 15 Dec 2010

    Keywords

    • bi-orientation
    • chromosome segregation
    • kinetochore
    • microtubule
    • mitosis
    • SPINDLE-ASSEMBLY CHECKPOINT
    • BIPOLAR CHROMOSOME ATTACHMENT
    • NEWT LUNG-CELLS
    • AURORA-B
    • MITOTIC-SPINDLE
    • FISSION YEAST
    • BUDDING YEAST
    • SACCHAROMYCES-CEREVISIAE
    • OUTER KINETOCHORE
    • NDC80 COMPLEX

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