Kinetochore-microtubule interactions: the means to the end

Tomoyuki U. Tanaka, Arshad Desai

    Research output: Contribution to journalReview article

    82 Citations (Scopus)

    Abstract

    Kinetochores are proteinaceous complexes containing dozens of components; they are assembled at centromeric DNA regions and provide the major microtubule attachment site on chromosomes during cell division. Recent studies have defined the kinetochore components comprising the direct interface with spindle microtubules, primarily through structural and functional analysis of the Ndc80 and Dam1 complexes. These studies have facilitated our understanding of how kinetochores remain attached to the end of dynamic microtubules and how proper orientation of a kinetochore-microtubule attachment is promoted on the mitotic spindle. In this article, we review these recent studies and summarize their key findings.

    Original languageEnglish
    Pages (from-to)53-63
    Number of pages11
    JournalCurrent Opinion in Cell Biology
    Volume20
    Issue number1
    DOIs
    Publication statusPublished - Feb 2008

    Keywords

    • YEAST SACCHAROMYCES-CEREVISIAE
    • SPINDLE-ASSEMBLY CHECKPOINT
    • NEWT LUNG-CELLS
    • MITOTIC SPINDLE
    • AURORA-B
    • BUDDING YEAST
    • FISSION YEAST
    • DASH COMPLEX
    • CHROMOSOME SEGREGATION
    • RING COMPLEX

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