Kinetoplastids: related protozoan pathogens, different diseases

Ken Stuart; Reto Brun; Simon Croft; Alan Fairlamb; Ricardo E. Guertler; Jim McKerrow; Steve Reed; Rick Tarleton

doi:10.1172/JCI33945

Kinetoplastids: related protozoan pathogens, different diseases

Ken Stuart, Reto Brun, Simon Croft, Alan Fairlamb, Ricardo E. Guertler, Jim McKerrow, Steve Reed, Rick Tarleton

Research output: Contribution to journal › Review article › peer-review

460 Citations (Scopus)

300 Downloads (Pure)

Abstract

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.

Original language	English
Pages (from-to)	1301-1310
Number of pages	10
Journal	Journal of Clinical Investigation
Volume	118
Issue number	4
DOIs	https://doi.org/10.1172/JCI33945
Publication status	Published - 2008

Keywords

TRYPANOSOMA-CRUZI INFECTION
WORLD CUTANEOUS LEISHMANIASIS
INDIAN VISCERAL LEISHMANIASIS
GAMBIENSE SLEEPING SICKNESS
LIPOSOMAL AMPHOTERICIN-B
CARD-AGGLUTINATION-TEST
CHRONIC CHAGAS-DISEASE
AMERICAN TRYPANOSOMIASIS
TRIATOMA-INFESTANS
CELL-DEVELOPMENT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1172/JCI33945

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Aref#d: 18185. Characterization and validation of drug targets in the Kinetoplastida (Principal Research Fellowship/Programme Grant)
Fairlamb, A. (Investigator)
1/10/06 → 30/09/17
Project: Research

Cite this

@article{6070dae224d64f02bf7582e6857ae064,

title = "Kinetoplastids: related protozoan pathogens, different diseases",

abstract = "Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these {"}neglected diseases{"} are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.",

keywords = "TRYPANOSOMA-CRUZI INFECTION, WORLD CUTANEOUS LEISHMANIASIS, INDIAN VISCERAL LEISHMANIASIS, GAMBIENSE SLEEPING SICKNESS, LIPOSOMAL AMPHOTERICIN-B, CARD-AGGLUTINATION-TEST, CHRONIC CHAGAS-DISEASE, AMERICAN TRYPANOSOMIASIS, TRIATOMA-INFESTANS, CELL-DEVELOPMENT",

author = "Ken Stuart and Reto Brun and Simon Croft and Alan Fairlamb and Guertler, {Ricardo E.} and Jim McKerrow and Steve Reed and Rick Tarleton",

year = "2008",

doi = "10.1172/JCI33945",

language = "English",

volume = "118",

pages = "1301--1310",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "American Society for Clinical Investigation",

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T1 - Kinetoplastids

T2 - related protozoan pathogens, different diseases

AU - Stuart, Ken

AU - Brun, Reto

AU - Croft, Simon

AU - Fairlamb, Alan

AU - Guertler, Ricardo E.

AU - McKerrow, Jim

AU - Reed, Steve

AU - Tarleton, Rick

PY - 2008

Y1 - 2008

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AB - Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.

KW - TRYPANOSOMA-CRUZI INFECTION

KW - WORLD CUTANEOUS LEISHMANIASIS

KW - INDIAN VISCERAL LEISHMANIASIS

KW - GAMBIENSE SLEEPING SICKNESS

KW - LIPOSOMAL AMPHOTERICIN-B

KW - CARD-AGGLUTINATION-TEST

KW - CHRONIC CHAGAS-DISEASE

KW - AMERICAN TRYPANOSOMIASIS

KW - TRIATOMA-INFESTANS

KW - CELL-DEVELOPMENT

U2 - 10.1172/JCI33945

DO - 10.1172/JCI33945

M3 - Review article

C2 - 18382742

SN - 0021-9738

VL - 118

SP - 1301

EP - 1310

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 4

ER -

Kinetoplastids: related protozoan pathogens, different diseases

Abstract

Keywords

UN SDGs

Access to Document

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Projects

Aref#d: 18185. Characterization and validation of drug targets in the Kinetoplastida (Principal Research Fellowship/Programme Grant)

Cite this