Knockout and transgenic mice in glutathione transferase research

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    Abstract

    Glutathione transferases (GSTs) are a multigene family of ubiquitously expressed, polymorphic enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates, play a central role in the adaptive response to chemical and oxidative stress, and are subject to regulation by a range of structurally unrelated chemicals. In this review, we present a current summary of knockout mouse models in the GST field, discussing some of the issues pertaining to orthologous proteins between mice and humans, the potential confounding issues related to genetic background, and also cover new transgenic models in the increasingly important area of humanization.

    Original languageEnglish
    Pages (from-to)152-164
    Number of pages13
    JournalDrug Metabolism Reviews
    Volume43
    Issue number2
    DOIs
    Publication statusPublished - May 2011

    Keywords

    • Glutathione transferase
    • transgenic
    • knockout
    • humanization
    • PREGNANE-X-RECEPTOR
    • AGE-AT-ONSET
    • CONSTITUTIVE ANDROSTANE RECEPTOR
    • DRUG-METABOLIZING-ENZYMES
    • GST-PI EXPRESSION
    • S-TRANSFERASE
    • OMEGA-CLASS
    • FUNCTIONAL-CHARACTERIZATION
    • SACCHAROMYCES-CEREVISIAE
    • HETEROLOGOUS EXPRESSION

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