Laboratory evolution of protein conformational dynamics

Eleanor C Campbell, Galen J Correy, Peter D Mabbitt, Ashley M Buckle, Nobuhiko Tokuriki, Colin J Jackson

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume50
DOIs
Publication statusPublished - Jun 2018

Keywords

  • Computer Simulation
  • Evolution, Molecular
  • Molecular Dynamics Simulation
  • Protein Conformation
  • Protein Engineering
  • Proteins/chemistry

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  • Cite this

    Campbell, E. C., Correy, G. J., Mabbitt, P. D., Buckle, A. M., Tokuriki, N., & Jackson, C. J. (2018). Laboratory evolution of protein conformational dynamics. Current Opinion in Structural Biology, 50, 49-57. https://doi.org/10.1016/j.sbi.2017.09.005