Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease

Letizia Santinelli; Neringa Pratuseviciute; Lara M. Lange; Teresa Kleinz; Norbert Brüggemann; Linn Streubel-Gallasch; Meret Möller; Alexander Zimprich; Christof Brücke; Jean Marc Good; Norman Griebner; Shalini Padmanabhan; Philip Seibler; Peter Bauer; Wim Vandenberghe; Esther Sammler; Cornelis Blauwendraat; Christine Klein; Max Borsche

doi:10.1002/mds.70291

Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease

Letizia Santinelli
, Neringa Pratuseviciute
, Lara M. Lange
, Teresa Kleinz
, Norbert Brüggemann
, Linn Streubel-Gallasch
, Meret Möller
, Alexander Zimprich
, Christof Brücke
, Jean Marc Good
, Norman Griebner
, Shalini Padmanabhan
, Philip Seibler
, Peter Bauer
, Wim Vandenberghe
, Esther Sammler
, Cornelis Blauwendraat
, Christine Klein
, Max Borsche (Lead / Corresponding author)

Research output: Contribution to journal › Letter › peer-review

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Original language	English
Pages (from-to)	1605-1608
Number of pages	4
Journal	Movement Disorders
Volume	41
Issue number	6
Early online date	30 Mar 2026
DOIs	https://doi.org/10.1002/mds.70291
Publication status	Published - 26 Jun 2026

Keywords

biomarker
kinase activity
LRRK2 Y1699C
monogenic Parkinson's disease
SAA
seed amplification assay
VPS35 D620N
α-synuclein

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.70291Licence: CC BY

Final published version
2026 The Author(s). Movement Disorders published by Wiley Periodi-cals LLC on behalf of International Parkinson and Movement DisorderSociety.This is an open access article under the terms of the CreativeCommons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 367 KBLicence: CC BY

Cite this

Santinelli, L., Pratuseviciute, N., Lange, L. M., Kleinz, T., Brüggemann, N., Streubel-Gallasch, L., Möller, M., Zimprich, A., Brücke, C., Good, J. M., Griebner, N., Padmanabhan, S., Seibler, P., Bauer, P., Vandenberghe, W., Sammler, E., Blauwendraat, C., Klein, C., & Borsche, M. (2026). Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease. Movement Disorders, 41(6), 1605-1608. https://doi.org/10.1002/mds.70291

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title = "Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease",

keywords = "biomarker, kinase activity, LRRK2 Y1699C, monogenic Parkinson's disease, SAA, seed amplification assay, VPS35 D620N, α-synuclein",

author = "Letizia Santinelli and Neringa Pratuseviciute and Lange, \{Lara M.\} and Teresa Kleinz and Norbert Br{\"u}ggemann and Linn Streubel-Gallasch and Meret M{\"o}ller and Alexander Zimprich and Christof Br{\"u}cke and Good, \{Jean Marc\} and Norman Griebner and Shalini Padmanabhan and Philip Seibler and Peter Bauer and Wim Vandenberghe and Esther Sammler and Cornelis Blauwendraat and Christine Klein and Max Borsche",

year = "2026",

month = jun,

day = "26",

doi = "10.1002/mds.70291",

language = "English",

volume = "41",

pages = "1605--1608",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "Wiley",

number = "6",

}

Santinelli, L, Pratuseviciute, N, Lange, LM, Kleinz, T, Brüggemann, N, Streubel-Gallasch, L, Möller, M, Zimprich, A, Brücke, C, Good, JM, Griebner, N, Padmanabhan, S, Seibler, P, Bauer, P, Vandenberghe, W, Sammler, E, Blauwendraat, C, Klein, C & Borsche, M 2026, 'Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease', Movement Disorders, vol. 41, no. 6, pp. 1605-1608. https://doi.org/10.1002/mds.70291

TY - JOUR

T1 - Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease

AU - Santinelli, Letizia

AU - Pratuseviciute, Neringa

AU - Lange, Lara M.

AU - Kleinz, Teresa

AU - Brüggemann, Norbert

AU - Streubel-Gallasch, Linn

AU - Möller, Meret

AU - Zimprich, Alexander

AU - Brücke, Christof

AU - Good, Jean Marc

AU - Griebner, Norman

AU - Padmanabhan, Shalini

AU - Seibler, Philip

AU - Bauer, Peter

AU - Vandenberghe, Wim

AU - Sammler, Esther

AU - Blauwendraat, Cornelis

AU - Klein, Christine

AU - Borsche, Max

PY - 2026/6/26

Y1 - 2026/6/26

KW - biomarker

KW - kinase activity

KW - LRRK2 Y1699C

KW - monogenic Parkinson's disease

KW - SAA

KW - seed amplification assay

KW - VPS35 D620N

KW - α-synuclein

UR - https://www.scopus.com/pages/publications/105034522488

U2 - 10.1002/mds.70291

DO - 10.1002/mds.70291

M3 - Letter

C2 - 41912440

AN - SCOPUS:105034522488

SN - 0885-3185

VL - 41

SP - 1605

EP - 1608

JO - Movement Disorders

JF - Movement Disorders

IS - 6

ER -

Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Establishment of a Data- and Biobank of Patients With VPS35 Mutations

Cite this

Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Projects

Establishment of a Data- and Biobank of Patients With VPS35 Mutations

Cite this