Lack of nontargeted effects in murine bone marrow after low-dose in vivo X irradiation

Nikolay A. Zyuzikov, Philip J. Coates, John M. Parry, Sally A. Lorimore, Eric G. Wright

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    27 Citations (Scopus)

    Abstract

    Exposure to high doses of ionizing radiation unequivocally produces adverse health effects including malignancy. At low doses the situation is much less clear, because effects are generally too small to be estimated directly by epidemiology, and extrapolation of risk and establishment of international rules and standards rely on the linear no-threshold (LNT) concept. Claims that low doses are more damaging than would be expected from LNT have been made on the basis of in vitro studies of nontargeted bystander effects and genomic instability, but relevant investigations of primary cells and tissues are limited. Here we show that after low-dose low-LET in vivo radiation exposures in the 0-100-mGy range of murine bone marrow there is no evidence of a bystander effect, assessed by p53 pathway signaling, nor is there any evidence for longer-term chromosomal instability in the bone marrow at doses below 1000 mGy. The data are not consistent with speculations based on in vitro nontargeted effects that low-dose X radiation is more damaging than would be expected from linear extrapolation.
    Original languageEnglish
    Pages (from-to)322-7
    Number of pages6
    JournalRadiation Research
    Volume175
    Issue number3
    DOIs
    Publication statusPublished - 2011

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    Bystander Effect
    bone marrow
    Bone Marrow
    Linear Energy Transfer
    dosage
    Chromosomal Instability
    irradiation
    Genomic Instability
    Ionizing Radiation
    Epidemiology
    X-Rays
    extrapolation
    Health
    epidemiology
    Neoplasms
    thresholds
    radiation dosage
    ionizing radiation
    health
    In Vitro Techniques

    Cite this

    Zyuzikov, N. A., Coates, P. J., Parry, J. M., Lorimore, S. A., & Wright, E. G. (2011). Lack of nontargeted effects in murine bone marrow after low-dose in vivo X irradiation. Radiation Research, 175(3), 322-7. https://doi.org/10.1667/RR2386.1
    Zyuzikov, Nikolay A. ; Coates, Philip J. ; Parry, John M. ; Lorimore, Sally A. ; Wright, Eric G. / Lack of nontargeted effects in murine bone marrow after low-dose in vivo X irradiation. In: Radiation Research. 2011 ; Vol. 175, No. 3. pp. 322-7.
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    abstract = "Exposure to high doses of ionizing radiation unequivocally produces adverse health effects including malignancy. At low doses the situation is much less clear, because effects are generally too small to be estimated directly by epidemiology, and extrapolation of risk and establishment of international rules and standards rely on the linear no-threshold (LNT) concept. Claims that low doses are more damaging than would be expected from LNT have been made on the basis of in vitro studies of nontargeted bystander effects and genomic instability, but relevant investigations of primary cells and tissues are limited. Here we show that after low-dose low-LET in vivo radiation exposures in the 0-100-mGy range of murine bone marrow there is no evidence of a bystander effect, assessed by p53 pathway signaling, nor is there any evidence for longer-term chromosomal instability in the bone marrow at doses below 1000 mGy. The data are not consistent with speculations based on in vitro nontargeted effects that low-dose X radiation is more damaging than would be expected from linear extrapolation.",
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    Zyuzikov, NA, Coates, PJ, Parry, JM, Lorimore, SA & Wright, EG 2011, 'Lack of nontargeted effects in murine bone marrow after low-dose in vivo X irradiation', Radiation Research, vol. 175, no. 3, pp. 322-7. https://doi.org/10.1667/RR2386.1

    Lack of nontargeted effects in murine bone marrow after low-dose in vivo X irradiation. / Zyuzikov, Nikolay A.; Coates, Philip J.; Parry, John M.; Lorimore, Sally A.; Wright, Eric G.

    In: Radiation Research, Vol. 175, No. 3, 2011, p. 322-7.

    Research output: Contribution to journalArticle

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