Laser-nucleated acoustic cavitation in focused ultrasound

Bjoern Gerold, Spiros Kotopoulis, Craig McDougall, David McGloin, Michiel Postema, Paul Prentice

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)


    Acoustic cavitation can occur in therapeutic applications of high-amplitude focused ultrasound. Studying acoustic cavitation has been challenging, because the onset of nucleation is unpredictable. We hypothesized that acoustic cavitation can be forced to occur at a specific location using a laser to nucleate a microcavity in a pre-established ultrasound field. In this paper we describe a scientific instrument that is dedicated to this outcome, combining a focused ultrasound transducer with a pulsed laser. We present high-speed photographic observations of laser-induced cavitation and laser-nucleated acoustic cavitation, at frame rates of 0.5 x 10(6) frames per second, from laser pulses of energy above and below the optical breakdown threshold, respectively. Acoustic recordings demonstrated inertial cavitation can be controllably introduced to the ultrasound focus. This technique will contribute to the understanding of cavitation evolution in focused ultrasound including for potential therapeutic applications. (C) 2011 American Institute of Physics. [doi:10.1063/1.3579499]

    Original languageEnglish
    Article number044902
    Pages (from-to)-
    Number of pages9
    JournalReview of Scientific Instruments
    Issue number4
    Publication statusPublished - Apr 2011




    Dive into the research topics of 'Laser-nucleated acoustic cavitation in focused ultrasound'. Together they form a unique fingerprint.

    Cite this