Learnings from leveraging OMOP and the HDR UK Cohort Discovery Service to accelerate recruitment to Dementia trials

Gordon Milligan; Erum Masood; Christian Cole; Doug McFadyen; Charlotte Weaver; William Whiteley

doi:10.20933/100001518

Learnings from leveraging OMOP and the HDR UK Cohort Discovery Service to accelerate recruitment to Dementia trials

Gordon Milligan
, Erum Masood
, Christian Cole
, Doug McFadyen
, Charlotte Weaver
, William Whiteley

Research output: Contribution to conference › Poster › peer-review

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Abstract

Alzheimer’s disease trials have recruited slowly in the UK. Challenges include diagnostic delays, measuring biomarkers, and under representation.

To address these challenges the Dementia Trials Accelerator (DTA) has:

1. Recruited a new Community-Based Phenotyping Trial-Ready Cohort
2. Harmonised this new cohort alongside existing UK consented cohorts to OMOP Common Data Model (CDM)
3. Enabled cross-cohort search using the Cohort Discovery Service (CDS) to supportmore efficient screening for dementia prevention and early-treatment trials.

Original language	English
DOIs	https://doi.org/10.20933/100001518
Publication status	Published - 10 Sept 2026
Event	OHDSI UK 2026 - Jubilee Hotel & Conferences, University of Nottingham, Nottingham, United Kingdom Duration: 17 Sept 2026 → 18 Sept 2026

Conference

Conference	OHDSI UK 2026
Country/Territory	United Kingdom
City	Nottingham
Period	17/09/26 → 18/09/26

Access to Document

10.20933/100001518Licence: CC BY

PosterFinal published version, 609 KBLicence: CC BY

1 Article

The Health Informatics Centre: a Regional Safe Haven and Trusted Research Environment Enabling World-Leading Research
Ward, L., Johnston, J., Milburn, K. R., Hall, C., Jones, C., Guignard-Duff, M., Krueger, S., Milligan, G., Hampton, J., Walls, R. & Cole, C., 16 Mar 2026, In: International Journal of Population Data Science. 8, 6, 13 p., 20.
Research output: Contribution to journal › Article › peer-review

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Cite this

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abstract = "Alzheimer{\textquoteright}s disease trials have recruited slowly in the UK. Challenges include diagnostic delays, measuring biomarkers, and under representation. To address these challenges the Dementia Trials Accelerator (DTA) has: 1. Recruited a new Community-Based Phenotyping Trial-Ready Cohort 2. Harmonised this new cohort alongside existing UK consented cohorts to OMOP Common Data Model (CDM) 3. Enabled cross-cohort search using the Cohort Discovery Service (CDS) to supportmore efficient screening for dementia prevention and early-treatment trials.",

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AU - Masood, Erum

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AU - McFadyen, Doug

AU - Weaver, Charlotte

AU - Whiteley, William

PY - 2026/9/10

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AB - Alzheimer’s disease trials have recruited slowly in the UK. Challenges include diagnostic delays, measuring biomarkers, and under representation. To address these challenges the Dementia Trials Accelerator (DTA) has: 1. Recruited a new Community-Based Phenotyping Trial-Ready Cohort 2. Harmonised this new cohort alongside existing UK consented cohorts to OMOP Common Data Model (CDM) 3. Enabled cross-cohort search using the Cohort Discovery Service (CDS) to supportmore efficient screening for dementia prevention and early-treatment trials.

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DO - 10.20933/100001518

M3 - Poster

T2 - OHDSI UK 2026

Y2 - 17 September 2026 through 18 September 2026

ER -

Learnings from leveraging OMOP and the HDR UK Cohort Discovery Service to accelerate recruitment to Dementia trials

Abstract

Conference

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Research output

The Health Informatics Centre: a Regional Safe Haven and Trusted Research Environment Enabling World-Leading Research

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Health Informatics Centre

Cite this