TY - JOUR
T1 - Lectin receptors expressed on myeloid cells
AU - Brown, Gordon D.
AU - Crocker, Paul R.
N1 - The authors thank the Wellcome Trust, Medical Research Council, and Arthritis Research UK for funding.
PY - 2016/9/23
Y1 - 2016/9/23
N2 - Lectins recognize a diverse array of carbohydrate structures and perform numerous essential biological functions. Here we focus on only two families of lectins, the Siglecs and C-type lectins. Triggering of intracellular signaling cascades following ligand recognition by these receptors can have profound effects on the induction and modulation of immunity. In this chapter, we provide a brief overview of each family and then focus on selected examples that highlight how these lectins can influence myeloid cell functioning in health and disease. Receptors that are discussed include Sn (Siglec-1), CD33 (Siglec-3), and Siglec-5, -7, -8, -9, -10, -11, -14, -15, -E, -F, and -G as well as Dectin-1, MICL, Dectin-2, Mincle/MCL, and the macrophage mannose receptor.
AB - Lectins recognize a diverse array of carbohydrate structures and perform numerous essential biological functions. Here we focus on only two families of lectins, the Siglecs and C-type lectins. Triggering of intracellular signaling cascades following ligand recognition by these receptors can have profound effects on the induction and modulation of immunity. In this chapter, we provide a brief overview of each family and then focus on selected examples that highlight how these lectins can influence myeloid cell functioning in health and disease. Receptors that are discussed include Sn (Siglec-1), CD33 (Siglec-3), and Siglec-5, -7, -8, -9, -10, -11, -14, -15, -E, -F, and -G as well as Dectin-1, MICL, Dectin-2, Mincle/MCL, and the macrophage mannose receptor.
U2 - 10.1128/microbiolspec.MCHD-0036-2016
DO - 10.1128/microbiolspec.MCHD-0036-2016
M3 - Review article
C2 - 27780012
SN - 2165-0497
VL - 4
SP - 1
EP - 26
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 5
ER -