Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

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• Finished

  State-of-the-Art Facilities for Structural Biology at the University of Dundee

  Hunter, B. (Investigator), Lilley, D. (Investigator), Owen-Hughes, T. (Investigator), Wyatt, P. (Investigator) & van Aalten, D. (Investigator)

  1/03/12 → 28/02/17

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Crystal Structure 82%
  • Enzyme 73%
  • Proteolysis 60%
  • Degrader 56%

• Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

  Fairlamb, A. (Investigator), Ferguson, M. (Investigator) & Frearson, J. (Investigator)

  1/01/08 → 31/12/12

  Project: Research

  • Trypanosoma Brucei 100%
  • Enzyme 49%
  • T. Brucei 38%
  • Crystal Structure 30%
  • Drug Discovery 28%

• Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

  Hunter, B. (Investigator)

  1/11/07 → 31/12/13

  Project: Research

  • Enzyme 100%
  • Crystal Structure 92%
  • Trypanosoma Brucei 69%
  • Active Sites 67%
  • Active Site 61%