Lemierre's Syndrome – A rare cause of disseminated sepsis requiring multi-organ support

John Rae (Lead / Corresponding author), Katie Misselbrook

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Lemierre's syndrome is a rare complication of acute pharyngitis characterised by septicaemia with infective thrombophlebitis of the internal jugular vein, most commonly due to Fusobacterium necrophorum. It characteristically affects healthy young adults causing persistent pyrexia and systemic sepsis presenting several days after an initial pharyngitis. Septic emboli seed via the bloodstream to distant sites including the lung, joints, skin, liver, spleen and brain. Prolonged antimicrobial therapy is required and admission to intensive care common. This once rare condition is increasing in incidence but awareness amongst clinicians is low. We present a classic case in a young man who developed multi-organ failure requiring intensive care support and describe the epidemiology, pathophysiology, microbiology, clinical features and management of the disease.

    Original languageEnglish
    Pages (from-to)329-333
    Number of pages5
    JournalJournal of the Intensive Care Society
    Volume18
    Issue number4
    Early online date14 Mar 2017
    DOIs
    Publication statusPublished - 1 Nov 2017

    Keywords

    • Fusobacterium necrophorum
    • Lemierre syndrome
    • postanginal sepsis
    • thrombophlebitis

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