Lenvatinib and its use in the treatment of unresectable hepatocellular carcinoma

Mark A. Baxter (Lead / Corresponding author), Hilary Glen, Thomas R. J. Evans

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)
    433 Downloads (Pure)

    Abstract

    Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver accounting for approximately 90% of cases. Patients often present at an advanced stage when treatment options are limited. Sorafenib, a multitargeted tyrosine kinase inhibitor, has been the first-line treatment in this setting for almost a decade. Several subsequent targeted therapies have failed to demonstrate significant improvement in survival. The results of the REFLECT study suggest that lenvatinib, a multikinase inhibitor, may have promised as a first-line treatment in patients with advanced HCC. This article will review the development of lenvatinib and the evidence behind its potential use in patients with advanced HCC.
    Original languageEnglish
    Pages (from-to)2021-2029
    Number of pages9
    JournalFuture Oncology
    Volume14
    Issue number20
    Early online date22 May 2018
    DOIs
    Publication statusPublished - Aug 2018

    Keywords

    • drug development
    • hepatocellular carcinoma
    • lenvatinib
    • multikinase inhibitor
    • pharmacokinetics
    • REFLECT
    • sorafenib

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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