Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver accounting for approximately 90% of cases. Patients often present at an advanced stage when treatment options are limited. Sorafenib, a multitargeted tyrosine kinase inhibitor, has been the first-line treatment in this setting for almost a decade. Several subsequent targeted therapies have failed to demonstrate significant improvement in survival. The results of the REFLECT study suggest that lenvatinib, a multikinase inhibitor, may have promised as a first-line treatment in patients with advanced HCC. This article will review the development of lenvatinib and the evidence behind its potential use in patients with advanced HCC.
- drug development
- hepatocellular carcinoma
- multikinase inhibitor
Baxter, M. A., Glen, H., & Evans, T. R. J. (2018). Lenvatinib and its use in the treatment of unresectable hepatocellular carcinoma. Future Oncology, 14(20), 2021-2029. https://doi.org/10.2217/fon-2017-0689