Leptin: a diverse regulator of neuronal function

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    114 Citations (Scopus)


    It is well documented that leptin is a circulating hormone that plays a key role in regulating food intake and body weight via its actions on specific hypothalamic nuclei. However, leptin receptors are widely expressed in the CNS, in regions not generally associated with energy homeostasis, such as the hippocampus, cortex and cerebellum. Moreover, evidence is accumulating that leptin has widespread actions in the brain. In particular, recent studies have demonstrated that leptin markedly influences the excitability of hippocampal neurons via its ability to activate large conductance Ca(2+)-activated K(+) (BK) channels, and also to promote long-term depression of excitatory synaptic transmission. Here, we review the evidence supporting a role for this hormone in regulating hippocampal excitability.
    Original languageEnglish
    Pages (from-to)307-313
    Number of pages7
    JournalJournal of Neurochemistry
    Issue number2
    Publication statusPublished - Jan 2007


    • Animals
    • Hippocampus
    • Humans
    • Leptin
    • Neurons
    • Potassium Channels, Calcium-Activated
    • Receptors, Cell Surface
    • Receptors, Leptin
    • Receptors, N-Methyl-D-Aspartate
    • Synaptic Transmission


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