Leptin: A multifaceted hormone in the central nervous system

Jenni Harvey (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    48 Citations (Scopus)

    Abstract

    It is well established that the adipocyte-derived hormone leptin is an important circulating satiety factor that regulates body weight and food intake via its actions on specific hypothalamic nuclei. However, there is growing evidence that leptin and its receptors are widely expressed throughout the brain, in regions not generally associated with energy homeostasis, such as cortex, cerebellum, brainstem, basal ganglia, and hippocampus. In this review the author discusses recent advances made in leptin neurobiology, with particular emphasis on the role of this endocrine peptide in normal and pathophysiological hippocampal function.

    Original languageEnglish
    Pages (from-to)245-258
    Number of pages14
    JournalMolecular Neurobiology
    Volume28
    Issue number3
    DOIs
    Publication statusPublished - Dec 2003

    Keywords

    • BK channels
    • Hippocampus
    • Leptin
    • MAPK
    • NMDA receptor
    • PI 3-kinase

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