Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

Lynne J. Shanley, Andrew J. Irving, Mark G. Rae, Mike L. J. Ashford, Jenni Harvey

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    Abstract

    Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.
    Original languageEnglish
    Pages (from-to)299-300
    Number of pages2
    JournalNature Neuroscience
    Volume5
    Issue number4
    DOIs
    Publication statusPublished - Apr 2002

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    Keywords

    • Leptin metabolism
    • Neuronal plasticity physiology
    • Receptors
    • N-Methyl-D-Aspartate metabolism
    • NMDA
    • Synaptic transmission physiology

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