Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

Lynne J. Shanley; Andrew J. Irving; Mark G. Rae; Mike L. J. Ashford; Jenni Harvey

doi:10.1038/nn824

Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

Lynne J. Shanley, Andrew J. Irving, Mark G. Rae, Mike L. J. Ashford, Jenni Harvey

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.

Original language	English
Pages (from-to)	299-300
Number of pages	2
Journal	Nature Neuroscience
Volume	5
Issue number	4
DOIs	https://doi.org/10.1038/nn824
Publication status	Published - Apr 2002

Keywords

Leptin metabolism
Neuronal plasticity physiology
Receptors
N-Methyl-D-Aspartate metabolism
NMDA
Synaptic transmission physiology

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10.1038/nn824

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title = "Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels",

abstract = "Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.",

keywords = "Leptin metabolism, Neuronal plasticity physiology, Receptors, N-Methyl-D-Aspartate metabolism, NMDA, Synaptic transmission physiology",

author = "Shanley, {Lynne J.} and Irving, {Andrew J.} and Rae, {Mark G.} and Ashford, {Mike L. J.} and Jenni Harvey",

note = "dc.publisher: Nature Publishing Group dc.description.sponsorship: Wellcome Trust (grant nos. 055291 & 042726) ",

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T1 - Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

AU - Shanley, Lynne J.

AU - Irving, Andrew J.

AU - Rae, Mark G.

AU - Ashford, Mike L. J.

AU - Harvey, Jenni

N1 - dc.publisher: Nature Publishing Group dc.description.sponsorship: Wellcome Trust (grant nos. 055291 & 042726)

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AB - Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.

KW - Leptin metabolism

KW - Neuronal plasticity physiology

KW - Receptors

KW - N-Methyl-D-Aspartate metabolism

KW - NMDA

KW - Synaptic transmission physiology

U2 - 10.1038/nn824

DO - 10.1038/nn824

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SP - 299

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JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 4

ER -

Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

Abstract

Keywords

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