Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.
- Leptin metabolism
- Neuronal plasticity physiology
- N-Methyl-D-Aspartate metabolism
- Synaptic transmission physiology
Shanley, L. J., Irving, A. J., Rae, M. G., Ashford, M. L. J., & Harvey, J. (2002). Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nature Neuroscience, 5(4), 299-300. https://doi.org/10.1038/nn824