Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

Lynne J. Shanley, Andrew J. Irving, Mark G. Rae, Mike L. J. Ashford, Jenni Harvey

    Research output: Contribution to journalArticle

    70 Citations (Scopus)

    Abstract

    Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.
    Original languageEnglish
    Pages (from-to)299-300
    Number of pages2
    JournalNature Neuroscience
    Volume5
    Issue number4
    DOIs
    Publication statusPublished - Apr 2002

    Fingerprint

    Calcium-Activated Potassium Channels
    KATP Channels
    Leptin
    Large-Conductance Calcium-Activated Potassium Channels
    Neurons
    Leptin Receptors
    1-Phosphatidylinositol 4-Kinase
    Hypothalamus
    Adenosine Triphosphate

    Keywords

    • Leptin metabolism
    • Neuronal plasticity physiology
    • Receptors
    • N-Methyl-D-Aspartate metabolism
    • NMDA
    • Synaptic transmission physiology

    Cite this

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    title = "Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels",
    abstract = "Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.",
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    author = "Shanley, {Lynne J.} and Irving, {Andrew J.} and Rae, {Mark G.} and Ashford, {Mike L. J.} and Jenni Harvey",
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    Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. / Shanley, Lynne J.; Irving, Andrew J.; Rae, Mark G.; Ashford, Mike L. J.; Harvey, Jenni.

    In: Nature Neuroscience, Vol. 5, No. 4, 04.2002, p. 299-300.

    Research output: Contribution to journalArticle

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    AU - Shanley, Lynne J.

    AU - Irving, Andrew J.

    AU - Rae, Mark G.

    AU - Ashford, Mike L. J.

    AU - Harvey, Jenni

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    KW - Neuronal plasticity physiology

    KW - Receptors

    KW - N-Methyl-D-Aspartate metabolism

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