Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

TY - JOUR

T1 - Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

AU - Shanley, Lynne J.

AU - Irving, Andrew J.

AU - Rae, Mark G.

AU - Ashford, Mike L. J.

AU - Harvey, Jenni

N1 - dc.publisher: Nature Publishing Group dc.description.sponsorship: Wellcome Trust (grant nos. 055291 & 042726)

PY - 2002/4

Y1 - 2002/4

N2 - Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.

AB - Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)-driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.

KW - Leptin metabolism

KW - Neuronal plasticity physiology

KW - Receptors

KW - N-Methyl-D-Aspartate metabolism

KW - NMDA

KW - Synaptic transmission physiology

U2 - 10.1038/nn824

DO - 10.1038/nn824

M3 - Article

C2 - 11889470

SN - 1097-6256

VL - 5

SP - 299

EP - 300

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 4

ER -