Leptin regulation of synaptic function at hippocampal TA-CA1 and SC-CA1 synapses

Jenni Harvey (Lead / Corresponding author)

    Research output: Chapter in Book/Report/Conference proceedingChapter

    3 Citations (Scopus)

    Abstract

    Increasing evidence indicates that the metabolic hormone, leptin markedly influences the functioning of the hippocampus. In particular, exposure to leptin results in persistent changes in synaptic efficacy at both temporoammonic (TA) and Schaffer Collateral (SC) inputs to hippocampal CA1 neurons. The ability of leptin to regulate TA-CA1 and SC-CA1 synapses has important functional implications, as both synaptic connections play important roles in hippocampal-dependent learning and memory. Here we review the modulatory actions of the hormone leptin at these hippocampal CA1 synapses and explore the impact on learning and memory processes.

    Original languageEnglish
    Title of host publicationHormones, Regulators and Hippocampus
    EditorsGerald Litwack
    PublisherAcademic Press Inc.
    Chapter10
    Pages315-336
    Number of pages22
    Volume118
    ISBN (Electronic)9780323992213
    ISBN (Print)9780323992213
    DOIs
    Publication statusPublished - 16 Feb 2022

    Publication series

    NameVitamins and Hormones
    Volume118
    ISSN (Print)0083-6729

    Keywords

    • AMPA receptor
    • Hippocampus
    • Leptin
    • NMDA receptor
    • Synaptic plasticity
    • Temporoammonic

    ASJC Scopus subject areas

    • Physiology
    • Endocrinology

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