Leptin regulation of synaptic function at hippocampal TA-CA1 and SC-CA1 synapses

Jenni Harvey (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Increasing evidence indicates that the metabolic hormone, leptin markedly influences the functioning of the hippocampus. In particular, exposure to leptin results in persistent changes in synaptic efficacy at both temporoammonic (TA) and Schaffer Collateral (SC) inputs to hippocampal CA1 neurons. The ability of leptin to regulate TA-CA1 and SC-CA1 synapses has important functional implications, as both synaptic connections play important roles in hippocampal-dependent learning and memory. Here we review the modulatory actions of the hormone leptin at these hippocampal CA1 synapses and explore the impact on learning and memory processes.

Original languageEnglish
Title of host publicationHormones, Regulators and Hippocampus
EditorsGerald Litwack
PublisherAcademic Press Inc.
Chapter10
Pages315-336
Number of pages22
Volume118
ISBN (Electronic)9780323992213
ISBN (Print)9780323992213
DOIs
Publication statusPublished - 16 Feb 2022

Publication series

NameVitamins and Hormones
Volume118
ISSN (Print)0083-6729

Keywords

  • AMPA receptor
  • Hippocampus
  • Leptin
  • NMDA receptor
  • Synaptic plasticity
  • Temporoammonic

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

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