Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma: Preliminary results and rationale

R. Stephens (Lead / Corresponding author), J. Holmes, E. Eadie

Research output: Contribution to journalLetterpeer-review

11 Downloads (Pure)

Abstract

Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression.

Original languageEnglish
Pages (from-to)e628-e630
Number of pages2
JournalJournal of the European Academy of Dermatology and Venereology
Volume34
Issue number10
Early online date20 Apr 2020
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • Photodynamic therapy
  • BCC
  • IPL
  • haemoglobin optical‐coherence‐tomography (OCT)
  • compression

Fingerprint

Dive into the research topics of 'Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma: Preliminary results and rationale'. Together they form a unique fingerprint.

Cite this