TY - JOUR
T1 - Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma
T2 - Preliminary results and rationale
AU - Stephens, R.
AU - Holmes, J.
AU - Eadie, E.
N1 - This article is protected by copyright. All rights reserved.
PY - 2020/4/20
Y1 - 2020/4/20
N2 - Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression.
AB - Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression.
KW - Photodynamic therapy
KW - BCC
KW - IPL
KW - haemoglobin optical‐coherence‐tomography (OCT)
KW - compression
UR - http://www.scopus.com/inward/record.url?scp=85084968058&partnerID=8YFLogxK
U2 - 10.1111/jdv.16503
DO - 10.1111/jdv.16503
M3 - Letter
C2 - 32311807
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
ER -