Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma:  Preliminary results and rationale

R. Stephens; J. Holmes; E. Eadie

doi:10.1111/jdv.16503

Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma: Preliminary results and rationale

R. Stephens (Lead / Corresponding author)
, J. Holmes
, E. Eadie

MED Undergraduate Medicine

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

186 Downloads (Pure)

Abstract

Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression.

Original language	English
Pages (from-to)	e628-e630
Number of pages	2
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	34
Issue number	10
Early online date	20 Apr 2020
DOIs	https://doi.org/10.1111/jdv.16503
Publication status	Published - 1 Oct 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Photodynamic therapy
BCC
IPL
haemoglobin optical‐coherence‐tomography (OCT)
compression

ASJC Scopus subject areas

Infectious Diseases
Dermatology

Access to Document

10.1111/jdv.16503

Author Accepted ManuscriptAccepted author manuscript, 5.16 MB

Cite this

@article{72d3931204f942dc9231b92c18bd78fc,

title = "Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma: Preliminary results and rationale",

abstract = "Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression. ",

keywords = "Photodynamic therapy, BCC, IPL, haemoglobin optical‐coherence‐tomography (OCT), compression",

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Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma: Preliminary results and rationale. / Stephens, R. (Lead / Corresponding author); Holmes, J.; Eadie, E.
In: Journal of the European Academy of Dermatology and Venereology, Vol. 34, No. 10, 01.10.2020, p. e628-e630.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Lesion compression during light activation may improve efficacy of photodynamic treatment of basal cell carcinoma

T2 - Preliminary results and rationale

AU - Stephens, R.

AU - Holmes, J.

AU - Eadie, E.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression.

AB - Roozeboom et al reported high recurrence rates at 3 years for photodynamically‐treated superficial‐BCCs, particularly on the head and neck of younger patients. Vasculature within the dermis is more prominent in these areas and flushing is more noticeable when lesions on faces are treated (personal observation) (Fig.1). Therefore, we hypothesize that haemoglobin may be interfering with treatment. We present PDT of BCCs using methylaminolevulinic‐acid (MAL) cream with a modified protocol. Activation is performed in 2 phases; a first‐phase using 630nm red‐light (Aktilite CL16, Galderma, Sweden) immediately followed by a second‐phase using intense‐pulsed‐light (IPL) (BBL, Sciton, Ca, USA) with long‐pulsed, non‐thermal settings and applied with compression to the lesion to blanch the skin. Fig.1 shows typical blanching from compression.

KW - Photodynamic therapy

KW - BCC

KW - IPL

KW - haemoglobin optical‐coherence‐tomography (OCT)

KW - compression

UR - https://www.scopus.com/pages/publications/85084968058

U2 - 10.1111/jdv.16503

DO - 10.1111/jdv.16503

M3 - Letter

C2 - 32311807

SN - 0926-9959

VL - 34

SP - e628-e630

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

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ER -