Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332

C. Roland Wolf; Colin J. Henderson; Michael Schwarz; Francesco Inesta-Vaquera; Richard R. Meehan

doi:10.1080/10408444.2025.2601199

Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332

C. Roland Wolf (Lead / Corresponding author)
, Colin J. Henderson
, Michael Schwarz
, Francesco Inesta-Vaquera
, Richard R. Meehan

Cancer Research

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Critical Reviews in Toxicology
Early online date	19 Jan 2026
DOIs	https://doi.org/10.1080/10408444.2025.2601199
Publication status	E-pub ahead of print - 19 Jan 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Toxicology

Access to Document

10.1080/10408444.2025.2601199

Cite this

Wolf, C. R., Henderson, C. J., Schwarz, M., Inesta-Vaquera, F., & Meehan, R. R. (2026). Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332. Critical Reviews in Toxicology, 1-3. Advance online publication. https://doi.org/10.1080/10408444.2025.2601199

Wolf, C. Roland ; Henderson, Colin J. ; Schwarz, Michael et al. / Letter to the editor regarding the review article : Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332. In: Critical Reviews in Toxicology. 2026 ; pp. 1-3.

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title = "Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549{\textendash}586. doi: 10.1080/10408444.2025.2513332",

author = "Wolf, \{C. Roland\} and Henderson, \{Colin J.\} and Michael Schwarz and Francesco Inesta-Vaquera and Meehan, \{Richard R.\}",

year = "2026",

month = jan,

day = "19",

doi = "10.1080/10408444.2025.2601199",

language = "English",

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journal = "Critical Reviews in Toxicology",

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Wolf, CR , Henderson, CJ, Schwarz, M, Inesta-Vaquera, F & Meehan, RR 2026, 'Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332', Critical Reviews in Toxicology, pp. 1-3. https://doi.org/10.1080/10408444.2025.2601199

Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332. / Wolf, C. Roland (Lead / Corresponding author); Henderson, Colin J.; Schwarz, Michael et al.
In: Critical Reviews in Toxicology, 19.01.2026, p. 1-3.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Letter to the editor regarding the review article

T2 - Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332

AU - Wolf, C. Roland

AU - Henderson, Colin J.

AU - Schwarz, Michael

AU - Inesta-Vaquera, Francesco

AU - Meehan, Richard R.

PY - 2026/1/19

Y1 - 2026/1/19

UR - https://www.scopus.com/pages/publications/105028219062

U2 - 10.1080/10408444.2025.2601199

DO - 10.1080/10408444.2025.2601199

M3 - Letter

C2 - 41552896

AN - SCOPUS:105028219062

SN - 1040-8444

SP - 1

EP - 3

JO - Critical Reviews in Toxicology

JF - Critical Reviews in Toxicology

ER -

Wolf CR , Henderson CJ, Schwarz M, Inesta-Vaquera F, Meehan RR. Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549–586. doi: 10.1080/10408444.2025.2513332. Critical Reviews in Toxicology. 2026 Jan 19;1-3. Epub 2026 Jan 19. doi: 10.1080/10408444.2025.2601199

UN SDGs

ASJC Scopus subject areas

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