Leukocyte adhesion: a fundamental process in leukocyte physiology

C. G. Gahmberg, L. Valmu, L. Tian, P. Kotovuori, S. Fagerholm, A. Kotovuori, C. Kantor, T. Hilden

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.

    Original languageEnglish
    Pages (from-to)511-517
    Number of pages7
    JournalBrazilian Journal of Medical and Biological Research
    Issue number5
    Publication statusPublished - May 1999


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