Leukocyte adhesion: an integrated molecular process at the leukocyte plasma membrane

Carl G. Gahmberg, Leena Valmu, Annika Kotovuori, Pekka Kotovuori, Tiina J. Hilden, Susanna Fagerholm, Carmela Kantor, Tuula Nurminen, Eveliina Ihanus, Li Tian

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    Abstract

    Leukocyte adhesion is of pivotal functional importance, because most leukocyte functions depend on cell-cell contact. It must be strictly controlled, both at the level of specificity and strength of interaction, and therefore several molecular systems are involved. The most important leukocyte adhesion molecules are the selectins, the leukocyte-specific ß(2)-integrins and the intercellular adhesion molecules. The selectins induce an initial weak contact between cells, whereas firm adhesion is achieved through integrin-intercellular adhesion molecular binding. Although studies during the past twenty years have revealed several important features of leukocyte adhesion much is still poorly understood, and further work dealing with several aspects of adhesion is urgently needed. In this short essay, we review some recent developments in the field.

    Original languageEnglish
    Pages (from-to)273-281
    Number of pages9
    JournalBioscience Reports
    Volume19
    Issue number4
    DOIs
    Publication statusPublished - Aug 1999

    Cite this

    Gahmberg, C. G., Valmu, L., Kotovuori, A., Kotovuori, P., Hilden, T. J., Fagerholm, S., Kantor, C., Nurminen, T., Ihanus, E., & Tian, L. (1999). Leukocyte adhesion: an integrated molecular process at the leukocyte plasma membrane. Bioscience Reports, 19(4), 273-281. https://doi.org/10.1023/A:1020594223755