Leukocyte integrins and inflammation

C. G. Gahmberg, L. Valmu, S. Fagerholm, P. Kotovuori, E. Ihanus, L. Tian, T. Pessa-Morikawa

    Research output: Contribution to journalReview articlepeer-review

    89 Citations (Scopus)

    Abstract

    Leukocyte adhesion is of pivotal functional importance. Without adequate adhesion, T lymphocytes and natural killer cells are not cytotoxic, B cells cannot develop into antibody secreting plasma cells, leukocytes do not home into inflamed tissues and myeloid cells are not able to phagocytize or exhibit chemotactic responses. During evolution several leukocyte adhesion molecules have developed belonging to a few molecular families. Among these, the leukocyte-specific integrins (ß 2 integrins, CD11/CD18 molecules) are among the most important. Much progress has taken place during the past few years, and at present we have a considerable knowledge of their structure and function. Inflammation is critically dependent on integrin activity, and its regulation forms the topic of this short review.

    Original languageEnglish
    Pages (from-to)549-555
    Number of pages7
    JournalCellular and Molecular Life Sciences
    Volume54
    Issue number6
    DOIs
    Publication statusPublished - Jun 1998

    Cite this