Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events mmong statin-treated patients: a meta-analysis

TY - JOUR

T1 - Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events mmong statin-treated patients

T2 - a meta-analysis

AU - Boekholdt, S. Matthijs

AU - Arsenault, Benoit J.

AU - Hovingh, G. Kees

AU - Mora, Samia

AU - Pedersen, Terje R.

AU - LaRosa, John C.

AU - Welch, K.M.A.

AU - Amarenco, Pierre

AU - DeMicco, David A.

AU - Tonkin, Andrew M.

AU - Sullivan, David R.

AU - Kirby, Adrienne

AU - Colhoun, Helen M.

AU - Hitman, Graham A.

AU - Betteridge, D. John

AU - Durrington, Paul N.

AU - Clearfield, Michael B.

AU - Downs, John R.

AU - Gotto, Antonio M.

AU - Ridker, Paul M.

AU - Kastelein, John J.P.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - It is unclear whether levels of high-density lipoprotein cholesterol (HDL-C) or apolipoprotein A-I (apoA-I) remain inversely associated with cardiovascular risk among patients who achieve very low levels of low-density lipoprotein cholesterol on statin therapy. It is also unknown whether a rise in HDL-C or apoA-I after initiation of statin therapy is associated with a reduced cardiovascular risk.

AB - It is unclear whether levels of high-density lipoprotein cholesterol (HDL-C) or apolipoprotein A-I (apoA-I) remain inversely associated with cardiovascular risk among patients who achieve very low levels of low-density lipoprotein cholesterol on statin therapy. It is also unknown whether a rise in HDL-C or apoA-I after initiation of statin therapy is associated with a reduced cardiovascular risk.

U2 - 10.1161/CIRCULATIONAHA.113.002670

DO - 10.1161/CIRCULATIONAHA.113.002670

M3 - Article

C2 - 23965489

SN - 0009-7322

VL - 128

SP - 1504

EP - 1512

JO - Circulation

JF - Circulation

IS - 14

ER -