Life in lights: tracking mitochondrial delivery to lysosomes in vivo

Thomas G. McWilliams, Ian G. Ganley (Lead / Corresponding author)

Research output: Contribution to journalComment/debate

9 Citations (Scopus)
137 Downloads (Pure)

Abstract

The past decade has seen an intensive and concerted research effort into the molecular regulation of mitophagy, the selective autophagy of mitochondria. Cell-based studies have implicated mitophagy in the pathology of diverse conditions ranging from cancer to neurodegeneration. However, a definitive link between mitophagy and the aetiology of human disease remains to be demonstrated. Moreover, we do not know how pervasive mammalian mitophagy is in vivo and fundamental questions remain unanswered. For example, is mitophagy common to all tissues under basal conditions or does it only occur in highly oxidative tissues under stress? This paucity of knowledge is largely due to a lack of experimentally tractable tools that can measure and monitor mitophagy in tissues. Our recent work describes the development of mito-QC, a mouse model to study mitophagy at single cell resolution in vivo.

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalAutophagy
Volume12
Issue number12
Early online date7 Oct 2016
DOIs
Publication statusPublished - 2016

Keywords

  • Autophagy
  • Brain
  • Development
  • Heart
  • Kidney
  • Mitochondria
  • Mitophagy
  • Tissues

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