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Abstract
Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change the overall response of the tissue, e.g., from solid-like to fluid-like. Mesoscopic mechanical properties of epithelia are commonly modeled with the vertex model. While previous studies have predominantly focused on the rheological properties of the vertex model at long time scales, we systematically studied the full dynamic range by applying small oscillatory shear and bulk deformations in both solid-like and fluid-like phases for regular hexagonal and disordered cell configurations. We found that the shear and bulk responses in the fluid and solid phases can be described by standard spring-dashpot viscoelastic models. Furthermore, the solid-fluid transition can be tuned by applying pre-deformation to the system. Our study provides insights into the mechanisms by which epithelia can regulate their rich rheological behavior.
Original language | English |
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Article number | e1010135 |
Number of pages | 24 |
Journal | PLoS Computational Biology |
Volume | 18 |
Issue number | 5 |
DOIs | |
Publication status | Published - 19 May 2022 |
Keywords
- Elasticity
- Epithelium
- Rheology
- Viscosity
ASJC Scopus subject areas
- Genetics
- Ecology, Evolution, Behavior and Systematics
- Cellular and Molecular Neuroscience
- Molecular Biology
- Ecology
- Computational Theory and Mathematics
- Modelling and Simulation
Fingerprint
Dive into the research topics of 'Linear viscoelastic properties of the vertex model for epithelial tissues'. Together they form a unique fingerprint.Projects
- 1 Finished
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Epithelial Sheet Dynamics during Primitive Streak Formation as Active Matter (joint with University of Aberdeen)
Sknepnek, R. (Investigator) & Weijer, K. (Investigator)
Biotechnology and Biological Sciences Research Council
1/04/16 → 30/10/19
Project: Research
Research output
- 19 Citations
- 1 Preprint
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Linear viscoelastic properties of the vertex model for epithelial tissues
Tong, S., Singh, N. K., Sknepnek, R. & Košmrlj, A., 27 Jan 2022, (E-pub ahead of print) arXiv, 36 p.Research output: Working paper/Preprint › Preprint
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