Projects per year
Abstract
Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.
Original language | English |
---|---|
Pages (from-to) | 190-201 |
Number of pages | 12 |
Journal | Journal of Cachexia, Sarcopenia and Muscle |
Volume | 8 |
Issue number | 2 |
Early online date | 8 Oct 2016 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- Fatty Acid
- Skeletal Muscle
- Atrophy
- Catabolism
- mTOR
- Lipid
- Obesity
Fingerprint
Dive into the research topics of 'Lipid modulation of skeletal muscle mass and function'. Together they form a unique fingerprint.Projects
- 3 Finished
-
Defining the Molecular Roles of Peripheral CB1 and CB2 Cannabinoid Receptors in Age-Induced Changes in Energy and Metabolic Homeostasis (Joint with University of Aberdeen)
Hundal, H. (Investigator) & Lipina, C. (Investigator)
Biotechnology and Biological Sciences Research Council
1/01/16 → 28/02/19
Project: Research
-
Wellcome Trust PhD Studentship
Cowling, V. (Investigator), Owen-Hughes, T. (Investigator) & Ryan, R. (Investigator)
1/09/15 → 5/09/19
Project: Research
-
Non-Genomic Mechanisms Stabilizing the Abundance of SNAT2, a Nutrient Transceptor Protein, in Response to Diverse Catabotic Signals
Hundal, H. (Investigator) & Taylor, P. (Investigator)
3/10/11 → 2/07/15
Project: Research