Lipid modulation of skeletal muscle mass and function

Christopher Lipina, Harinder S. Hundal (Lead / Corresponding author)

Research output: Contribution to journalReview article

31 Citations (Scopus)
103 Downloads (Pure)

Abstract

Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.
Original languageEnglish
Pages (from-to)190-201
Number of pages12
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume8
Issue number2
Early online date8 Oct 2016
DOIs
Publication statusPublished - Apr 2017

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Skeletal Muscle
Lipids
Dietary Supplements
Fatty Acids
Obesity
Pharmacology
Pathology
Neoplasms

Keywords

  • Fatty Acid
  • Skeletal Muscle
  • Atrophy
  • Catabolism
  • mTOR
  • Lipid
  • Obesity

Cite this

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title = "Lipid modulation of skeletal muscle mass and function",
abstract = "Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.",
keywords = "Fatty Acid, Skeletal Muscle, Atrophy, Catabolism, mTOR, Lipid, Obesity",
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T1 - Lipid modulation of skeletal muscle mass and function

AU - Lipina, Christopher

AU - Hundal, Harinder S.

N1 - Research in the authors’ laboratory is supported by funding from BBSRC and Diabetes UK.

PY - 2017/4

Y1 - 2017/4

N2 - Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.

AB - Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.

KW - Fatty Acid

KW - Skeletal Muscle

KW - Atrophy

KW - Catabolism

KW - mTOR

KW - Lipid

KW - Obesity

U2 - 10.1002/jcsm.12144

DO - 10.1002/jcsm.12144

M3 - Review article

C2 - 27897400

VL - 8

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JO - Journal of Cachexia, Sarcopenia and Muscle

JF - Journal of Cachexia, Sarcopenia and Muscle

SN - 2190-5991

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ER -