Lipid modulation of skeletal muscle mass and function

Christopher Lipina, Harinder S. Hundal (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

157 Citations (Scopus)
204 Downloads (Pure)


Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.
Original languageEnglish
Pages (from-to)190-201
Number of pages12
JournalJournal of Cachexia, Sarcopenia and Muscle
Issue number2
Early online date8 Oct 2016
Publication statusPublished - Apr 2017


  • Fatty Acid
  • Skeletal Muscle
  • Atrophy
  • Catabolism
  • mTOR
  • Lipid
  • Obesity


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