This paper describes the design and synthesis of lipophilic bioisosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The bioisostere is designed to mimic the conformation of the nucleoside triphosphate when complexed to a metal ion such as magnesium. Copyright (C) 1996 Elsevier Science Ltd.
|Number of pages||6|
|Journal||Bioorganic & Medicinal Chemistry Letters|
|Publication status||Published - 22 Oct 1996|