Lipophilic bioisosteres of nucleoside triphosphates

Alastair O.  Goldring; Ian H. Gilbert; Naheed Mahmood; Jan Balzarini

doi:10.1016/0960-894X(96)00443-X

Lipophilic bioisosteres of nucleoside triphosphates

Alastair O. Goldring, Ian H. Gilbert, Naheed Mahmood, Jan Balzarini

Research output: Contribution to journal › Article › peer-review

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Abstract

This paper describes the design and synthesis of lipophilic bioisosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The bioisostere is designed to mimic the conformation of the nucleoside triphosphate when complexed to a metal ion such as magnesium. Copyright (C) 1996 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2411-2416
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	6
Issue number	20
DOIs	https://doi.org/10.1016/0960-894X(96)00443-X
Publication status	Published - 22 Oct 1996

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title = "Lipophilic bioisosteres of nucleoside triphosphates",

abstract = "This paper describes the design and synthesis of lipophilic bioisosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The bioisostere is designed to mimic the conformation of the nucleoside triphosphate when complexed to a metal ion such as magnesium. Copyright (C) 1996 Elsevier Science Ltd.",

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AU - Gilbert, Ian H.

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AB - This paper describes the design and synthesis of lipophilic bioisosteres of nucleoside triphosphates as potential inhibitors of HIV reverse transcriptase. The bioisostere is designed to mimic the conformation of the nucleoside triphosphate when complexed to a metal ion such as magnesium. Copyright (C) 1996 Elsevier Science Ltd.

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DO - 10.1016/0960-894X(96)00443-X

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Lipophilic bioisosteres of nucleoside triphosphates

Abstract

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