Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em

Matthew I. Hutchings, Tracy Palmer, Dean J. Harrington, Iain C. Sutcliffe

    Research output: Contribution to journalReview articlepeer-review

    139 Citations (Scopus)

    Abstract

    Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.

    Original languageEnglish
    Pages (from-to)13-21
    Number of pages9
    JournalTrends in Microbiology
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - Jan 2009

    Keywords

    • ARGININE TRANSLOCATION PATHWAY
    • METHIONINE SULFOXIDE REDUCTASES
    • II SIGNAL PEPTIDASE
    • BACILLUS-SUBTILIS
    • STAPHYLOCOCCUS-AUREUS
    • ESCHERICHIA-COLI
    • MYCOBACTERIUM-TUBERCULOSIS
    • LISTERIA-MONOCYTOGENES
    • OUTER-MEMBRANE
    • STREPTOCOCCUS-PNEUMONIAE

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