Lipoprotein biogenesis in Gram-positive bacteria

knowing when to hold 'em, knowing when to fold 'em

Matthew I. Hutchings, Tracy Palmer, Dean J. Harrington, Iain C. Sutcliffe

    Research output: Contribution to journalReview article

    123 Citations (Scopus)

    Abstract

    Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.

    Original languageEnglish
    Pages (from-to)13-21
    Number of pages9
    JournalTrends in Microbiology
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - Jan 2009

    Keywords

    • ARGININE TRANSLOCATION PATHWAY
    • METHIONINE SULFOXIDE REDUCTASES
    • II SIGNAL PEPTIDASE
    • BACILLUS-SUBTILIS
    • STAPHYLOCOCCUS-AUREUS
    • ESCHERICHIA-COLI
    • MYCOBACTERIUM-TUBERCULOSIS
    • LISTERIA-MONOCYTOGENES
    • OUTER-MEMBRANE
    • STREPTOCOCCUS-PNEUMONIAE

    Cite this

    Hutchings, Matthew I. ; Palmer, Tracy ; Harrington, Dean J. ; Sutcliffe, Iain C. / Lipoprotein biogenesis in Gram-positive bacteria : knowing when to hold 'em, knowing when to fold 'em. In: Trends in Microbiology. 2009 ; Vol. 17, No. 1. pp. 13-21.
    @article{08ae68c839ef4b1294e39346f3ff3835,
    title = "Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em",
    abstract = "Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.",
    keywords = "ARGININE TRANSLOCATION PATHWAY, METHIONINE SULFOXIDE REDUCTASES, II SIGNAL PEPTIDASE, BACILLUS-SUBTILIS, STAPHYLOCOCCUS-AUREUS, ESCHERICHIA-COLI, MYCOBACTERIUM-TUBERCULOSIS, LISTERIA-MONOCYTOGENES, OUTER-MEMBRANE, STREPTOCOCCUS-PNEUMONIAE",
    author = "Hutchings, {Matthew I.} and Tracy Palmer and Harrington, {Dean J.} and Sutcliffe, {Iain C.}",
    year = "2009",
    month = "1",
    doi = "10.1016/j.tim.2008.10.001",
    language = "English",
    volume = "17",
    pages = "13--21",
    journal = "Trends in Microbiology",
    issn = "0966-842X",
    publisher = "Elsevier",
    number = "1",

    }

    Lipoprotein biogenesis in Gram-positive bacteria : knowing when to hold 'em, knowing when to fold 'em. / Hutchings, Matthew I.; Palmer, Tracy; Harrington, Dean J.; Sutcliffe, Iain C.

    In: Trends in Microbiology, Vol. 17, No. 1, 01.2009, p. 13-21.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Lipoprotein biogenesis in Gram-positive bacteria

    T2 - knowing when to hold 'em, knowing when to fold 'em

    AU - Hutchings, Matthew I.

    AU - Palmer, Tracy

    AU - Harrington, Dean J.

    AU - Sutcliffe, Iain C.

    PY - 2009/1

    Y1 - 2009/1

    N2 - Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.

    AB - Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.

    KW - ARGININE TRANSLOCATION PATHWAY

    KW - METHIONINE SULFOXIDE REDUCTASES

    KW - II SIGNAL PEPTIDASE

    KW - BACILLUS-SUBTILIS

    KW - STAPHYLOCOCCUS-AUREUS

    KW - ESCHERICHIA-COLI

    KW - MYCOBACTERIUM-TUBERCULOSIS

    KW - LISTERIA-MONOCYTOGENES

    KW - OUTER-MEMBRANE

    KW - STREPTOCOCCUS-PNEUMONIAE

    U2 - 10.1016/j.tim.2008.10.001

    DO - 10.1016/j.tim.2008.10.001

    M3 - Review article

    VL - 17

    SP - 13

    EP - 21

    JO - Trends in Microbiology

    JF - Trends in Microbiology

    SN - 0966-842X

    IS - 1

    ER -