Liposomal drug delivery to manage nontuberculous mycobacterial pulmonary disease and other chronic lung infections

James D. Chalmers (Lead / Corresponding author), Jakko van Ingen, Roald van der Laan, Jean-Louis Herrmann

    Research output: Contribution to journalReview articlepeer-review

    17 Citations (Scopus)
    102 Downloads (Pure)

    Abstract

    Nontuberculous mycobacterial (NTM) pulmonary disease is a chronic respiratory infection associated with declining lung function, radiological deterioration and significantly increased morbidity and mortality. Patients often have underlying lung conditions, particularly bronchiectasis and COPD. NTM pulmonary disease is difficult to treat because mycobacteria can evade host defences and antimicrobial therapy through extracellular persistence in biofilms and sequestration into macrophages. Management of NTM pulmonary disease remains challenging and outcomes are often poor, partly due to limited penetration of antibiotics into intracellular spaces and biofilms. Efficient drug delivery to the site of infection is therefore a key objective of treatment, but there is high variability in lung penetration by antibiotics. Inhalation is the most direct route of delivery and has demonstrated increased efficacy of antibiotics like amikacin compared with systemic administration. Liposomes are small, artificial, enclosed spherical vesicles, in which drug molecules can be encapsulated to provide controlled release, with potentially improved pharmacokinetics and reduced toxicity. They are especially useful for drugs where penetration of cell membranes is essential. Inhaled delivery of liposomal drug solutions can therefore facilitate direct access to macrophages in the lung where the infecting NTM may reside. A range of liposomal drugs are currently being evaluated in respiratory diseases.

    Original languageEnglish
    Article number210010
    Number of pages14
    JournalEuropean Respiratory Review
    Volume30
    Issue number161
    Early online date20 Jul 2021
    DOIs
    Publication statusPublished - 30 Sept 2021

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine

    Fingerprint

    Dive into the research topics of 'Liposomal drug delivery to manage nontuberculous mycobacterial pulmonary disease and other chronic lung infections'. Together they form a unique fingerprint.

    Cite this