Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System

Yasunori Hayashi (Lead / Corresponding author), Lenzie K. Ford, Luana Fioriti, Leeanne McGurk, Mingjie Zhang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
31 Downloads (Pure)


Molecules within cells are segregated into functional domains to form various organelles. While some of those organelles are delimited by lipid membranes demarcating their constituents, others lack a membrane enclosure. Recently, liquid-liquid phase separation (LLPS) revolutionized our view of how segregation of macromolecules can produce membraneless organelles. While the concept of LLPS has been well studied in the areas of soft matter physics and polymer chemistry, its significance has only recently been recognized in the field of biology. It occurs typically between macromolecules that have multivalent interactions. Interestingly, these features are present in many molecules that exert key functions within neurons. In this review, we cover recent topics of LLPS in different contexts of neuronal physiology and pathology.

Original languageEnglish
Pages (from-to)834-844
Number of pages11
JournalJournal of Neuroscience
Issue number5
Early online date15 Jan 2021
Publication statusPublished - 3 Feb 2021


  • liquid-liquid phase separation
  • local protein synthesis
  • membraneless organelle
  • neurodegenerative diseases
  • synapse


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