LKB1, a protein kinase regulating cell proliferation and polarity

Jérôme Boudeau, Gopal Sapkota, Dario R. Alessi

    Research output: Contribution to journalArticle

    140 Citations (Scopus)

    Abstract

    LKB1 is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome. Since its discovery in 1998, much research has focused on identification and characterisation of its cellular roles and analysing how LKB1 might be regulated. In this review we discuss exciting recent advances indicating that LKB1 functions as a tumour suppressor perhaps by controlling cell polarity. We also outline the current understanding of the molecular mechanisms by which LKB1 is regulated in vivo, through interaction with other proteins as well as by protein phosphorylation and prenylation.
    Original languageEnglish
    Pages (from-to)159-165
    Number of pages7
    JournalFEBS Letters
    Volume546
    Issue number1
    DOIs
    Publication statusPublished - 3 Jul 2003

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