LKB1, a protein kinase regulating cell proliferation and polarity

TY - JOUR

T1 - LKB1, a protein kinase regulating cell proliferation and polarity

AU - Boudeau, Jérôme

AU - Sapkota, Gopal

AU - Alessi, Dario R.

PY - 2003/7/3

Y1 - 2003/7/3

N2 - LKB1 is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome. Since its discovery in 1998, much research has focused on identification and characterisation of its cellular roles and analysing how LKB1 might be regulated. In this review we discuss exciting recent advances indicating that LKB1 functions as a tumour suppressor perhaps by controlling cell polarity. We also outline the current understanding of the molecular mechanisms by which LKB1 is regulated in vivo, through interaction with other proteins as well as by protein phosphorylation and prenylation.

AB - LKB1 is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome. Since its discovery in 1998, much research has focused on identification and characterisation of its cellular roles and analysing how LKB1 might be regulated. In this review we discuss exciting recent advances indicating that LKB1 functions as a tumour suppressor perhaps by controlling cell polarity. We also outline the current understanding of the molecular mechanisms by which LKB1 is regulated in vivo, through interaction with other proteins as well as by protein phosphorylation and prenylation.

U2 - 10.1016/S0014-5793(03)00642-2

DO - 10.1016/S0014-5793(03)00642-2

M3 - Article

C2 - 12829253

SN - 0014-5793

VL - 546

SP - 159

EP - 165

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -