Projects per year
Abstract
The identification of a complex containing the tumor suppressor LKB1 as
the critical upstream kinase required for the activation of
AMP-activated protein kinase (AMPK) by metabolic stress was reported in
an article in Journal of Biology in 2003. This finding represented the
first clear link between AMPK and cancer. Here we briefly discuss how
this discovery came about, and describe some of the insights, especially
into the role of AMPK in cancer, that have followed from it.In
September 2003, our groups published a joint paper 1 in Journal of
Biology (now BMC Biology) that identified the long-sought and elusive
upstream kinase acting on AMP-activated protein kinase (AMPK) as a
complex containing LKB1, a known tumor suppressor. Similar findings were
reported at about the same time by David Carling and Marian Carlson 2
and by Reuben Shaw and Lew Cantley 3; at the time of writing these three
papers have received between them a total of over 2,000 citations.
These findings provided a direct link between a protein kinase, AMPK,
which at the time was mainly associated with regulation of metabolism,
and another protein kinase, LKB1, which was known from genetic studies
to be a tumor suppressor. While the idea that cancer is in part a
metabolic disorder (first suggested by Warburg in the 1920s 4) is well
recognized today 5, this was not the case in 2003, and our paper perhaps
contributed towards its renaissance. The aim of this short review is to
recall how we made the original finding, and to discuss some of the
directions that these findings have taken the field in the ensuing ten
years.
Original language | English |
---|---|
Article number | 36 |
Pages (from-to) | 1-11 |
Number of pages | 11 |
Journal | BMC Biology |
Volume | 11 |
DOIs | |
Publication status | Published - 15 Apr 2013 |
Keywords
- DIABETIC-PATIENTS
- PEUTZ-JEGHERS-SYNDROME
- LKB1-AMPK PATHWAY
- TUMOR-SUPPRESSOR LKB1
- ACTIVATED PROTEIN-KINASE
- ACETYL-COA CARBOXYLASE
- YEAST SNF1
- GLUCOSE-UPTAKE
- UPSTREAM KINASES
- CELLULAR-ENERGY
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Dive into the research topics of 'LKB1 and AMPK and the cancer-metabolism link - ten years after'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Rab Detection Initiative (Joint with Stanford School of Medicine, Max Plank Institute, Neuroscience Research Australia and Parkinsons Institute California)
Alessi, D. (Investigator) & Davies, P. (Investigator)
1/08/16 → 31/07/21
Project: Research
-
Non-canonical Pathways for Regulation of AMPK (Senior Investigator Award)
Hardie, G. (Investigator)
1/04/12 → 30/09/17
Project: Research