TY - JOUR
T1 - Local field potential recordings from the pedunculopontine nucleus in a Parkinsonian patient
AU - Androulidakis, Alexandros G.
AU - Khan, Sadaquate
AU - Litvak, Vladimir
AU - Pleydell-Pearce, Christopher W.
AU - Brown, Peter
AU - Gill, Steven S.
PY - 2008/1/8
Y1 - 2008/1/8
N2 - The pedunculopontine nucleus has recently been introduced as a new therapeutic target for deep brain stimulation in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. Therefore, we looked for and demonstrated evidence of low frequency synchronization of activity in the pedunculopontine nucleus of a patient with Parkinson's disease that increased after treatment with dopamine and which might be mimicked by local deep brain stimulation at low frequency.
AB - The pedunculopontine nucleus has recently been introduced as a new therapeutic target for deep brain stimulation in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. Therefore, we looked for and demonstrated evidence of low frequency synchronization of activity in the pedunculopontine nucleus of a patient with Parkinson's disease that increased after treatment with dopamine and which might be mimicked by local deep brain stimulation at low frequency.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-40349100364&partnerID=MN8TOARS
U2 - 10.1097/WNR.0b013e3282f2e2d1
DO - 10.1097/WNR.0b013e3282f2e2d1
M3 - Article
SN - 0959-4965
VL - 19
SP - 59
EP - 62
JO - NeuroReport
JF - NeuroReport
IS - 1
ER -